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Adult Onset Still's Disease

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Adult Onset Still’s Disease

A rare form of Still’s disease—acute febrile onset of arthritis in adults.
Clinical findings Multiple remissions and exacerbations, reduced wrist extensibility, carpal ankylosis, distal interphalangeal joint involvement; other features include daily fever spikes, reduced range of motion of neck, pericarditis, pleural effusions, severe abdominal pain, evanescent pink macules most prominent when febrile.
Lab Normal rheumatoid factor, anti-nuclear antibody (ANA), complement.
Management NSAIDs, glucocorticoids, methotrexate; biologic response modifiers—e.g., TNF-alpha blockers, infliximab, etanercept, adalimumab, rituximab, cyclosporine and anakinra have been used to treat adult Still's disease.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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References in periodicals archive
Fever of unknown origin: a review of 20 patients with adult onset Still's Disease. Clin Rheumatol 2003; 22: 89-93.
Adult onset Still's disease; clinical and laboratory features, treatment and progress of 45 cases.
Spectrum of lymph node pathology in adult onset Still's disease; analysis of 12 patients with one follow up biopsy.
Adult onset Still's disease. Best Pract Res Clin Rheumatol 2008; 22: 773-92.
Adult onset still's disease
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