ameloblastoma

[ah-mel″o-blas-to´mah]

a locally invasive, highly destructive tumor of the jaw; called also adamantinoma.

pituitary ameloblastoma craniopharyngioma.

ad·a·man·ti·no·ma

(ad'-ŏ-man-ti-nō'mă),

1. A low-grade malignant tumor of long bones (predominantly tibia) marked by a proliferation of nests of basaloid cells with palisading at the periphery. Compare: ameloblastoma.

2. A rare, slow-growing but locally aggressive tumor; its histogenesis remains controversial. Approximately 200 cases have been reported since it was first described in 1913. The tumor occurs almost exclusively in the long bones; tumors in the tibia account for more than 80% of cases. The diaphysial region is the area most commonly affected. The histiologic features of adamantinomas have many variations that are present not only among patients but also among different areas of the same tumor. Metastases occur in approximately 15-20% of patients and typically appear in the lungs and local lymph nodes.

Farlex Partner Medical Dictionary © Farlex 2012

adamantinoma

An extremely rare, generally indolent malignant epithelial tumour, which arises almost exclusively in the tibia or fibula in the second to fifth decade in life.

Clinical findings
Swelling, pain, developing over months to years.

Imaging
Eccentric, well-circumscribed, and lytic lesion on plain films.

DiffDx
Osteofibrous dysplasia, fibrous dysplasia, aneurysmal bone cyst, chondromyxoid fibroma, chondrosarcoma.

Management
Wide resection or amputation.

Prognosis
Excellent; overall survival is 85% at 10 years, but lower without adequate margins. Metastases are rare at presentation but may occur in up to 30% of patients during the disease course.

am·e·lo·blas·to·ma

(am'el'ō-blas-tō'mă)

A benign odontogenic epithelial neoplasm; it behaves as a slowly growing expansile radiolucent tumor, occurs most commonly in the posterior regions of the mandible, and has a marked tendency to recur if inadequately excised.

[ameloblast + G. -oma, tumor]

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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References in periodicals archive

Congenital melanocarcinoma, melanotic adamantinoma, retinal anlage tumor, progonoma, and pigmented epulis of infancy.

Melanotic Neuroectodermal Tumor of Infancy

There have been no definitive guidelines for a treatment of adamantinoma. The preferred treatment is surgical management with wide margins, reconstruction if necessary and possible, or amputation [1].

Tibia Adamantinoma Resection and Reconstruction with a Custom-Made Total Tibia Endoprosthesis: A Case Report with 8-Year Follow-Up

To our knowledge, this is the oldest case in English literature of a patient with adamantinoma of the femur.

Femoral Adamantinoma: A Rare Lesion in an Elderly Patient in a Rare Location

The term 'adamantinoma' was introduced by Malassez in 1885 to denote the epithelial odontogenic tumor which had been recognized by Cuzak in 1827.

Adamantinoma and ameloblastoma: histologic homologues

Ghosh, "Adamantinoma of the upper jaw," The American Journal of Pathology, vol.

Dentigerous cyst or adenomatoid odontogenic tumor: clinical radiological and histopathological dilemma

Bir calismada izlemde tekrarlanan biyopside adamantinoma saptanmasi nedeniyle butun osteofibroz displazi tanili olgulara ekstraperiostal eksizyon onerilmektedir (11).

Newborn with pathologic fracture of the tibia: osteofibrous dysplasia/patolojik tibiya kirigi olan yenidogan: osteofibroz displazi

Later on, Mallasez introduced the term "adamantinoma" and Churchill finally named it as ameloblastoma in 1934.3 It represents 1% of all the tumours of mandibular and maxillary region and approxi-mately 10% of all odontogenic mandibular tu-mours.4

AMELOBLASTOMAS - SEVEN YEARS CLINICAL AUDIT

The lesion was further described in 1885 by Malassez, who called it an adamantinoma. The term ameloblastoma was coined by Ivy and Churchill in 1934 The term giant ameloblastoma should be reserved for lesions that are truly large and that cause gross asymmetry and regional dysfunction.

Giant ameloblastoma: Report of an extreme case and a description of its treatment

We report a case of a tibial adamantinoma that was treated with a limb salvage procedure utilizing an intercalary tibial allograft and a free vascularized osteocutaneous graft of the fibula.

Long-Term Follow-Up of Adamantinoma of the Tibia Complicated by Metastases and a Second Unrelated Primary Cancer: A Case Report and Literature Review

Keratin and Vimentin Expression in Carcinomas and Mesenchymal Tumors Carcinomas That Frequently Express Both Renal cell carcinoma Anaplastic thyroid carcinoma Endometrial carcinoma Thyroid carcinoma Sarcomatoid carcinoma Mesothelioma Myoepithelial carcinoma Metaplastic breast carcinoma Carcinomas That Rarely Express Both Breast carcinoma Ovarian carcinoma Gastrointestinal carcinoma Lung small cell carcinoma Lung non-small cell carcinoma Prostate carcinoma Mesenchymal Tumors That Frequently Express Both Synovial sarcoma Desmoplastic small round blue cell tumor Epithelioid sarcoma Epithelioid angiosarcoma Malignant rhabdoid tumor Leiomyosarcoma Chordoma Adamantinoma Table 4.

Application of Immunohistochemistry in Undifferentiated Neoplasms: A Practical Approach