Acute on Chronic Phenomenon

Endocrinology A clinical finding in castrated patients with prostate cancer in which injections of gonadotropin-releasing hormone evoke microsurges in testosterone and LH, lasting for days to weeks.
Medspeak Acute on chronic phenomena have been described in the liver (hepatic IVC obstruction), lungs (acute exacerbation of COPD), mental disorders (schizophrenia) and in virtually every system and chronic disease, and are thus not unique to the prostate.

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