Accutin

A short-chain disintegrin obtained from Agkistrodon acutus venom, which is homologous to other disintegrins. Accutin inhibits platelet aggregation stimulated by ADP, collagen, thrombin or thromboxane analogues by blocking fibrinogen binding to platelet glycoprotein IIb/IIIa in a dose-dependent fashion. Accutin’s RGD sequence is responsible for inhibiting adhesion of umbilical vein endothelial cells to immobilised fibrinogen, fibronectin and vitronectin. It effectively blocks angiogenesis and induces cell death by apoptosis.

References in periodicals archive

1998 Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin aVb3 antagonist and inducing apoptosis.

Isolation of bothrasperin, a disintegrin with potent platelet aggregation inhibitory activity, from the venom of the snake Bothrops asper

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