Medical

APEX2

APEX2

A gene on chromosome Xp11.21 that encodes a weak apurinic/apyrimidinic (AP endoDNAase), which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcription factors. APEX2 has robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA, and preferentially removes mismatched nucleotides; it also has robust 3'-phosphodiesterase-induced removal of 3'-damaged termini formed in DNA by oxidative agents. It is required for somatic hypermutation (SHM) and DNA cleavage step of class-switch recombination of immunoglobulin genes, as well as for proper cell cycle progression during proliferation of peripheral lymphocytes.
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References in periodicals archive
Bruker, APEX2 and SAINT, Bruker AXS Inc., Madison, Wisconsin, USA (2007).
Facile Synthesis, Crystal Growth, Quantum Chemical Studies of Electronic Structure and of the Profoundly Persuasive NLO Organic Crystal: Ethyl 4-[N,N-bis(p-toluenesulfonyl)]-Aminobenzoate
The Casella Dust Detective encompasses the Microdust Pro real time dust monitor, and the Apex2 air-sampling pump.
Improved monitoring for site operations
APEX2 [19] was used for data collection and SAINT [20] for cell refinement and data reduction.
Substituted 4-Acyl-5-methyl-2-phenyl-pyrazol-3-one-phenylhydrazones with Antioxidant Properties: X-Ray Crystal and Spectroscopic Studies
We used S4800 scanning electron microscopy (Hitachi, Tokyo, Japan) and an EDAX Genesis APEX2 system (Ametek, Paoli, PA, USA).
A Calcium Enterolith in a Patient with Crohn's Disease and Its In Vitro Dissolubility in Citric Acid
Company has introduced the next generation of its personal sampling pump: the Apex2 featuring Bluetooth 4.0 wireless connectivity and supporting Airwave app.
Bluetooth technology enables remote tracking of employee air-sampling
Manchester-based Heyrod is currently on site at five projects in Liverpool including APEX2 (a Liverpool University academic building), Hatton Gardens (a second Liverpool University site providing accommodation), The New Royal Liverpool Hospital, a new docklands exhibition centre and Sefton Street Block 4 (a privately-owned development).
builders'' MERCHANT signs PS1m contract; Merseyside Building Supplies secures deal with contractor
WORLDWIDE COMPUTER PRODUCTS NEWS-May 21, 2014-NXP Software's HD voice solution featured in the ZTE Blade APEX2 smartphone
NXP Software's HD voice solution featured in the ZTE Blade APEX2 smartphone
M2 EQUITYBITES-May 21, 2014-NXP Software's HD voice solution featured in the ZTE Blade APEX2 smartphone
NXP Software's HD voice solution featured in the ZTE Blade APEX2 smartphone
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