ALOXE3

A gene on chromosome 17p13.1 that encodes a member of the lipoxygenase family, which are catabolised by arachidonic acid-derived compounds. ALOXE3 is a hydroperoxide isomerase that synthesises a unique epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE), and activates the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR alpha) involved in epidermal differentiation.

Molecular pathology
ALOXE3 mutations cause nonbullous congenital ichthyosiform erythroderma.

References in periodicals archive

Mutations in transglutaminase 1 (TGM1), ALOXE3, ALOX12B, and ABCA12 genes have been implicated.

Ichthyosis vulgaris

ELOVL6, fatty acid elongase 6; CYP4F22/39, cytochrome P450 family F22 (in human) and F39 (in mouse); CERS3, ceramide synthase 3; ABCA12, ABC transporter 12; UGCG, UDP-glucose ceramide glucosyltransferase; GBA, [beta]-glucocerebrosidase; ALOXE3, epidermal-type lipoxygenase 3; ALOX12B, 12R-lipoxygenase; TGM1, transglutaminase 1.

Lipoquality control by phospholipase [A.sub.2] enzymes

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