DNA hypomethylation at
ALOX12 is associated with persistent wheezing in childhood.
Thymonin interacted with the inflammation-related targets Alox5, Alox12 TNFRSF1A, and PDGFRB.
Others are involved in the metabolism of arachidonic acid, such as ALOX12, PLA2G10, PLA2G4B, CYP1B1, and CYP2A6.
Disease or Function p-Value Molecules # Mole Annotation cules Mood disorders 3.73E--04 ADRA2B,
ALOX12, AQP4, CA9, 22 CACNB2, CCKBR, CHRNA1, CHR NB4, CHRNG, DDC, ESR1, GRIA3, GRIK2, GRIN1, KCNK2, MTNR 1A, MYOM1, NCAM1, NDUFS7, PDE11A, SCN11A, SCN2B Depressive disorder 7.90E--04 ADRA2B, AQP4, CACNB2, 14 CCKBR, CHRNA1, CHRNB4, CHRNG, ESR1, GRIA3, GRIN1, KCNK2, MYOM1, NCAM1, PDE11A Table 3 Effect of Rhodiola on genes involved in depression ([section]).
The contribution of cofactors is further exemplified by the case of Alox12, a granular layer protein important for epidermal barrier formation, which is induced by [DELTA]Np63[alpha] only in differentiating keratinocytes [68].
Koster, "P63 directly induces expression of Alox12, a regulator of epidermal barrier formation," Experimental Dermatology, vol.
Third, using a candidate-gene approach based on a literature search for air pollution associated genes we investigated separately a set of 739 CpGs in 38 antioxidant and inflammatory genes (TGFB1, ARG1, ARG2, GSTM1, GSTP1, NQO1, SOD2, GPX1, HMOX-1, CAT, GSTT1, EPHX1, NOS2, TNF, NFE2L2, GSS, GPX7, GPX2, GSTZ1, ALB, SRXN1, NOX5,
ALOX12, NCF2, AOX1, MPV17, SIRT2, MBL2, OXSR1, OXR1, NUDT1, DUOX2, EPX, PXDNL, PXDN, MPO, LPO, TPO) (Carlsten and Melen 2012; Chen et al.
Arachidonate 15-Lipoxygenases (ALOX15) and Arachidonate 12-Lipoxygenases (
ALOX12), members of the LOX family that oxygenate free polyenoic fatty acids, were two key enzymes to synthesize LXA4 [32].
ALOX12, UBE20.XPR1, MPPED2 (includes EC:744), VEGFA, DLGS.