AKAP79
AKAP79
A multivalent scaffold protein which positions enzymes near their substrates, and is modified in response to various signals, acting as a platform for signalling unit assembly. The AKAP79 signalling complex is located near the postsynaptic membrane in neurones and anchors two 2nd-messenger-regulated kinases (cAMP-dependent protein kinase and protein kinase C), and phosphatase 2B (calcineurin).Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
A mammalian scaffold protein, AKAP79, acts as a platform for the assembly of PKA, PKC, and calcineurin, a complex that is targeted to neuronal postsynaptic membranes where they colocalize with substrates (Klauck et al., 1996).
Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein.
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