AKAP12

A gene on chromosome 6q24-q25 that encodes a member of the structurally diverse A-kinase anchor protein (AKAP) family, which binds to the regulatory subunits (RI/RII) of protein kinase A (PKA), confining PKA to discrete locations within the cell based on different targeting motifs. AKAP12 is expressed in endothelial cells, fibroblasts and osteosarcoma cells, associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction.

Molecular pathology
AKAP12 antibodies may be produced in myasthenia gravis.

References in periodicals archive

Rapid determination of AKAP12 promoter methylation levels in peripheral blood using methylation-sensitive high resolution melting (MS-HRM) analysis: Application in colorectal cancer.

Limited Role of Promoter Methylation of MGMT and C13ORF18 in Triage of Low-Grade Squamous Intraepithelial Lesion

It was reported that miR-183 inhibited apoptosis in HCC cells by repressing the PDCD4 expression [9] or reduced the expression of tumor suppressor gene AKAP12 in human hepatocarcinogenesis [11].

Expression and significance of MicroRNA-183 in hepatocellular carcinoma

Miano, associate director of the Aab Cardiovascular Research Institute at the University of Rochester Medical Center had identified a number of genes that were activated or turned on by retinoids, one of which was AKAP12.

Because research in the cancer field suggested it was a tumor suppressor gene, named for its ability to hinder cancer cell growth, Miano honed in on AKAP12 to see if it might be a target of retinoids in the context of vascular disease.

Common drug for leukemia, psoriasis may fight vascular disease

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