Medical

A375

A375

A human amelanotic melanoma cell line used in cytokine research, as it is not influenced by many biomolecules—e.g., prostaglandin E2; lectins; bacterial endotoxins and cytokines such as IL2, TNF; interferons or colony stimulating factors. A375 cells are extremely sensitive to growth-inhibitory effects of oncostatin M.
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References in periodicals archive
Proteomics analysis of' kojic acid treated A375 human malignant melanoma cells.
Wei et al., "Tubeimoside-1 inhibits growth via the induction of cell cycle arrest and apoptosis in human melanoma A375 cells," Bangladesh Journal of Pharmacology, vol.
Tsay, "Toxicogenomics of kojic acid on gene expression profiling of A375 human malignant melanoma cells," Biological and Pharmaceutical Bulletin, vol.
Moreover, POL showed remarkable anti-HSV-II activity towards Vero cells, cytotoxicity towards human melanoma A375 cells and induced apoptosis in a caspase-dependent manner.
To assess the biological function of NOP14 in melanoma cell lines A375 and SK-ML110, NOP14 overexpression and empty vectors were transiently transfected into cells.
Our finding are further supported by previous research reports where BHS-1 has been shown to inhibits STAT3 activation in A375 human melanoma, A431 human epidermoid carcinoma,U266 multiple myeloma and U937 acute myeloid leukemia cells (Khan et al., 2015).
134 - EXPRESSION OF NATIVE AND MUTATED ACVR1 IN TRANSIENTLY TRANSFECTED HUMAN A375 MELANOMA CELLS.
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