Medical

3,5,3'-triiodothyronine

3,5,3'-tri·i·o·do·thy·ro·nine (TITh, T3),

(trī-ī'ō-dō-thī'rō-nēn),
A thyroid hormone normally synthesized in smaller quantities than thyroxine; present in blood and thyroid gland and exerts the same biologic effects as thyroxine but, on a molecular basis, is more potent and its onset is more rapid.
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References in periodicals archive
High-fat diet increases thyrotropin and oxygen consumption without altering circulating 3,5,3'-triiodothyronine (T3) and thyroxine in rats: the role of iodothyroninedeiodinases,reverseT3production,andwhole-body fat oxidation.
3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity.
Nielsen et al., "Sources of circulating 3,5,3'-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases," The Journal of Clinical Endocrinology & Metabolism, vol.
Serum concentrations of free 3,5,3',5'-tetraiodothyronine [free thyroxine (f[T.sub.4)] and free 3,5,3'-triiodothyronine (f[T.sub.3)) were measured with electrochemiluminescence immunoassay (ECLIA) by using commercial kits.
Serum samples were protected from light and separated in Eppendorf tubes and stored at -4[degrees]C for determining the levels of thyrotropin-releasing hormone (TRH), 3,5,3'-triiodothyronine ([T.sub.3]), 3,5,3',5'-tetraiodothyronine ([T.sub.4]), cortisol (COR), and corticosterone (CORt) using a radioimmunoassay counter (Sn-69513, Shanghai Rihuan Photoelectric Instrument Co., Ltd, Shanghai, China).
The postnatal serum 3,5,3'-triiodothyronine ([T.sub.3]) surge in the rat is largely independent of extrathyroidal 5'-deiodination of thyroxine to [T.sub.3].
Effect of 3,5,3'-triiodothyronine (T3) administration on diol gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice.
Furthermore, the characterized T4 degradation product is not 3,5,3'-triiodothyronine (T3) since its HPLC elution profile was different from that of T3 itself.
Does a combination regimen of thyroxine (T4) and 3,5,3'-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism?
Transport of 3,5,3'-triiodothyronine into the perfused rat liver and subsequent metabolism are inhibited by fasting.
Whole-body thyroxine ([T.sub.4]) content (a measure of total circulating [T.sub.4]) in fish exposed to 100 mg/L perchlorate was elevated compared with the [T.sub.4] content of control fish, but 3,5,3'-triiodothyronine ([T.sub.3]) content was not significantly affected in any exposure group.
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