zymogen

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Related to Zymogens: Isoenzymes, Isozymes

zymogen

 [zi´mo-jen]
an inactive precursor that is converted into an active enzyme by action of an acid or another enzyme or by other means; a proenzyme. adj., adj zymogen´ic.

pro·en·zyme

(prō-en'zīm),
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active; for example, pepsinogen, trypsinogen, profibrolysin.
Synonym(s): zymogen

zymogen

(zī′mə-jən)
n.

zymogen

an inactive precursor that is converted into an active enzyme by action of an acid, another enzyme, or other means.

pro·en·zyme

(prō-en'zīm)
The precursor of an enzyme, requiring some change (usually the hydrolysis of an inhibiting fragment that masks an active grouping) to render it active, e.g., pepsinogen, trypsinogen, profibrinolysin.
Synonym(s): zymogen.

zymogen

The inactive protein precursor of an ENZYME.

zymogen

an inactive precursor of an enzyme, particularly those concerned with protein digestion, for example, PEPSINOGEN and TRYPSINOGEN. Zymogens require ACTIVATION ENERGY to become functional.

zymogen

an inactive precursor that is converted into an active enzyme by action of an acid or another enzyme or by other means; a proenzyme.

zymogen cells
the secretory cells that secrete the zymogens.
zymogen granules
contained in the cytoplasm of the secretory cells in the relevant gland. Contain the zymogen.
References in periodicals archive ?
1983) Identification of monkey lung procathepsin D-II as a pepsinogen-C-like acid protease zymogen.
1985) Purification of Japanese monkey prostate acid protease zymogen and its identification as a pepsinogen c-like zymogen.
Alcohol and zymogen activation in the pancreatic acinar cell.
Ethanol augments elevated-[Ca2+] C induced trypsin activation in pancreatic acinar zymogen granules.
Semisulcatus, with the appearance of numerous zymogen granules in the F-cells corresponding to a maximal rate of enzyme discharge into the tubule lumen.
Trypsin from Pacifastacus leniusculus hepatopancreas: purification and cDNA cloning of the synthesized zymogen.
All caspases are produced in cells as inactive zymogens and require a proteolytic cleavage and then convert to active form during apoptosis.
Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes.
Zymograms were incubated in the presence of 5 mmol/L EDTA and 2 mmol/L 1,10-phenanthroline for inhibition studies (31); activation of zymogens was achieved with 2 mmol/L p-aminophenyl-mercuric acetate (31).
Coordinated control is achieved by the action of trypsin as the common activator of all pancreatic zymogens.
Trypsin is secreted as the zymogen trypsinogen; it is converted in the intestine into the active enzyme trypsin by an enzyme called enterokinase.
Enzymes that digest proteins could potentially be harmful to the pancreatic cells themselves, so these enzymes are synthesized and stored until needed within the cells as protectively coated zymogen granules.