Zollinger-Ellison syndrome

Zol·lin·ger-El·li·son syndrome (zln-jr-l-sn)

n.

A gastrointestinal disease characterized by chronic peptic ulcers, gastric hypersecretion, and gastrinomas of the pancreatic islets of Langerhans.

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Zollinger-Ellison syndrome

A rare condition characterized by severe and recurrent peptic ulcers in the stomach, duodenum, and upper small intestine, caused by a tumor, or tumors, usually found in the pancreas. The tumor secretes the hormone gastrin, which stimulates the stomach and duodenum to produce large quantities of acid, leading to ulceration. Most often cancerous, the tumor must be removed surgically; otherwise total surgical removal of the stomach is necessary.

Mentioned in: Gastric Acid Determination, Ulcer Surgery, Ulcers

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Zollinger-Ellison syndrome,

n.pr a condition characterized by severe peptic ulceration, gastric hypersecretion, elevated serum gastrin, and gastrinoma of the pancreas or the duodenum. It may occur in early childhood but is seen more commonly in people between 20 and 50 years of age. Two thirds of the tumors are malignant. Total gastrectomy may be necessary, but the administration of cimetidine in large doses may control gastric hypersecretion and allow the ulcers to heal.

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Zollinger-Ellison syndrome

a triad comprising intractable, sometimes fulminating, upper gastrointestinal ulceration, extreme gastric hyperacidity, and nonbeta cell, gastrin-secreting, islet cell tumors (gastrinomas) of the pancreas. Clinical signs in affected dogs include vomiting, often with blood, anemia, diarrhea, weight loss, and sometimes signs of peritonitis.