Zollinger-Ellison syndrome


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Related to Zollinger-Ellison syndrome: dyspepsia, carcinoid syndrome

Zollinger-Ellison syndrome

 [zol´in-jer el´ĭ-sun]
a triad comprising intractable, sometimes fulminating, atypical peptic ulcers; extreme gastric hyperacidity; and non--beta-cell, gastrin-secreting islet cell tumors (gastrinomas) of the pancreas, which may be single or multiple, small or large, benign or malignant.

Zol·lin·ger-El·li·son syn·drome (ZES),

(zŏl'inj-er el'ĭ-son), [MIM*131100]
peptic ulceration with gastric hypersecretion and gastrinoma of the pancreas or duodenum, sometimes associated with familial multiple endocrine adenomatosis type 1.

Zol·lin·ger-El·li·son syn·drome (ZES),

(zŏl'inj-er el'ĭ-son), [MIM*131100]
peptic ulceration with gastric hypersecretion and gastrinoma of the pancreas or duodenum, sometimes associated with familial multiple endocrine adenomatosis type 1.

Zollinger-Ellison syndrome

(zŏl′ĭn-jər-ĕl′ĭ-sən)
n.
A gastrointestinal disease characterized by chronic peptic ulcers, gastric hypersecretion, and pancreatic gastrinomas.

Zollinger-Ellison syndrome

[zol′injər el′isən]
Etymology: Robert M. Zollinger, American surgeon, 1903-1992; Edwin H. Ellison, American physician, 1918-1970
a condition characterized by severe peptic ulceration, gastric hypersecretion, elevated serum gastrin, and gastrinoma of the pancreas or the duodenum. The syndrome is uncommon and occurs in a bipolar distribution such as in early childhood but is seen more frequently in people between 20 and 50 years of age. Two thirds of the tumors are malignant. Total gastrectomy may be necessary, but the administration of cimetidine in large doses may control gastric hypersecretion and allow the ulcers to heal. See also peptic ulcer.

Zollinger-Ellison syndrome

A condition characterized by multiple duodenal ulcers and gastrin-secreting tumors that cause recurrent and refractory upper GI ulceration, diarrhea, steatorrhea, hypoglycemia–due to excess 'little' gastrin, pyrosis and dysphagia due to gastroesophageal reflux and ↑ gastric acid; 25% also have MEN-I; malignant gastric carcinoid may be related to chronic gastrin hypersecretion Diagnosis CT, typical clinical findings Lab ↑ Gastrin, ↑ basal acid output–>15 mmol/hr, ↑ post-histamine stimulation acid production, ↑ ratio of basal acid output to maximum acid output–stimulation testing reveals fasting gastrin > 1000 pg/mL, ↑ Ca2+ DiffDx-hypergastrinemia Antral hyperplasia, retained antrum syndrome, chronic atrophic gastritis, pernicious anemia, short bowel syndrome, gastric outlet syndrome or obstruction, gastric CA, pheochromocytoma, renal failure Management H2 receptor antagonists; at higher doses may be coadministered with antimuscarinics to inhibit gastric secretion by H2 blockage; if unresponsive, total gastrectomy and/or vagotomy

Zol·lin·ger-El·li·son syn·drome

(zol'in-jĕr-el'i-sŏn sin'drōm)
Peptic ulceration with gastric hypersecretion and non-beta cell tumor of the pancreatic islets, sometimes associated with familial polyendocrine adenomatosis.

Zollinger-Ellison syndrome

A severe form of stomach and duodenal ulceration caused by an excessive production of acid by the stomach. This is stimulated by one or more tumours of the pancreas, known as gastrinomas, that secrete a powerful hormone acting on the stomach. Gastrinomas are often malignant, although slow-growing. Complete surgical removal is not always possible and drugs in the H-2 receptor antagonist group, such as cimetidine, or the more recent proton pump blocking drugs, such as OMEPRAZOLE, are often used. Removal of the stomach (gastrectomy) may be necessary. (Robert Milton Zollinger, b. 1903, American surgeon; and Edwin Horner Ellison, 1918–70, American professor of Surgery).

Zollinger-Ellison syndrome

A rare condition characterized by severe and recurrent peptic ulcers in the stomach, duodenum, and upper small intestine, caused by a tumor, or tumors, usually found in the pancreas. The tumor secretes the hormone gastrin, which stimulates the stomach and duodenum to produce large quantities of acid, leading to ulceration. Most often cancerous, the tumor must be removed surgically; otherwise total surgical removal of the stomach is necessary.

Ellison,

Edwin Homer, U.S. physician, 1918-1970.
Zollinger-Ellison syndrome - see under Zollinger
Zollinger-Ellison tumor - see under Zollinger

Reichmann,

Mikola, Polish physician, 1851-1918.
Reichmann disease - Synonym(s): Zollinger-Ellison syndrome

Zollinger,

Robert M., U.S. surgeon, 1903-1992.
Zollinger leg holder
Zollinger multipurpose tissue forceps
Zollinger splint
Zollinger-Ellison syndrome - peptic ulceration with gastric hypersecretion and non--beta cell tumor of the pancreatic islets, sometimes associated with familial polyendocrine adenomatosis.Synonym(s): Reichmann disease
Zollinger-Ellison tumor - a non-beta cell tumor of pancreatic islets causing the Zollinger-Ellison syndrome.

Zol·lin·ger-El·li·son syn·drome

(zol'in-jĕr-el'i-sŏn sin'drōm) [MIM*131100]
Peptic ulceration with gastric hypersecretion and non-beta cell tumor of the pancreatic islets, sometimes associated with familial polyendocrine adenomatosis.

Zollinger-Ellison syndrome,

n.pr a condition characterized by severe peptic ulceration, gastric hypersecretion, elevated serum gastrin, and gastrinoma of the pancreas or the duodenum. It may occur in early childhood but is seen more commonly in people between 20 and 50 years of age. Two thirds of the tumors are malignant. Total gastrectomy may be necessary, but the administration of cimetidine in large doses may control gastric hypersecretion and allow the ulcers to heal.

Zollinger-Ellison syndrome

a triad comprising intractable, sometimes fulminating, upper gastrointestinal ulceration, extreme gastric hyperacidity, and nonbeta cell, gastrin-secreting, islet cell tumors (gastrinomas) of the pancreas. Clinical signs in affected dogs include vomiting, often with blood, anemia, diarrhea, weight loss, and sometimes signs of peritonitis.
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And now NEXIUM is indicated for the long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison Syndrome.
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Stimulation of gastrin secretion in patients suspected of having Zollinger-Ellison Syndrome to aid in the diagnosis of gastrinoma.
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In addition, Aciphex is approved for the treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome, a rare disorder that causes the stomach to produce excess acid.
Aciphex also is approved for the treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome, a rare disorder that causes the stomach to produce excess acid.