Zoladex


Also found in: Dictionary.

Zoladex

 [zo´lah-deks]
trademark for preparations of goserelin, a gonadotropin suppressor used as an antineoplastic agent and to treat endometriosis.

goserelin acetate

Zoladex, Zoladex LA (CA) (UK), Zoladex 3-Month

Pharmacologic class: Gonadotropin-releasing hormone (GnRH) analog

Therapeutic class: Antineoplastic, hormone

Pregnancy risk category D (breast cancer), X (endometriosis)

Pregnancy risk category D (breast cancer), X (endometriosis)

Action

Synthetic form of luteinizing hormone-releasing hormone (LHRH); inhibits gonadotropin production by acting directly on pituitary gland. Enhances release of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone, lowering testosterone and estradiol levels.

Availability

Implant: 3.6 mg, 10.8 mg (in preloaded syringes)

Indications and dosages

Palliative treatment of advanced prostate cancer

Adults: 3.6 mg subcutaneously q 4 weeks or 10.8 mg subcutaneously q 12 weeks into upper abdominal wall

Adjunct to radiation therapy and flutamide in stage B2-C prostate cancer

Adults: 3.6 mg subcutaneously q 4 weeks starting on day 1 of radiation or during last week of radiation. Alternatively, 3.6 mg subcutaneously 8 weeks before radiation, then 10.8 mg on day 28 or 3.6 mg at 4-week intervals starting 8 weeks before radiation, for a total of four doses (two depots before and two during radiation therapy).

Palliative treatment of advanced breast cancer in pre- and perimenopausal women

Adults: 3.6 mg subcutaneously q 4 weeks. If serum estradiol doesn't fall to postmenopausal levels, may increase to 7.2 mg q 4 weeks.

Endometriosis

Adults ages 18 and older: 3.6 mg subcutaneously q 4 weeks, continued for 6 months

Endometrial thinning before ablation for dysfunctional uterine bleeding

Adults: 3.6 mg subcutaneously 4 weeks before surgery. Alternatively, initial 3.6-mg dose may be followed 4 weeks later by a second 3.6-mg dose, with surgery 2 to 4 weeks after second dose.

Contraindications

• Hypersensitivity to drug or its components or to GnRH, GnRH agonist analogs
• Pregnant patients

Precautions

Use cautiously in:
• risk factors for osteoporosis
• chronic alcohol or tobacco use
• patients receiving drugs that affect bone density
• hyperglycemia, cardiovascular risk factors
• breastfeeding patients
• children younger than age 18 (safety not established).

Administration

• Administer pretreatment pregnancy test to female of childbearing age.
• Know that drug should be given only by a clinician experienced in its use.
• Implant is placed subcutaneously into upper abdominal wall using aseptic technique. Give local anesthetic and stretch skin with one hand. Insert needle into subcutaneous fat, then change needle angle until it parallels abdominal wall. Push needle in until hub touches patient's skin, and withdraw about 1 ml before depressing plunger all the way.
• Don't aspirate after inserting needle. Blood will be visible in syringe if needle enters blood vessel.

Don't give by I.V. route.
• Be aware that 10.8-mg implant should not be used in women.
• Be aware that if implant must be removed, it can be located by ultrasound.

Adverse reactions

CNS: headache, anxiety, depression, dizziness, fatigue, insomnia, lethargy, pain, emotional lability, weakness, cerebrovascular accident, spinal cord compression

CV: vasodilation, chest pain, hypertension, palpitations, peripheral edema, myocardial infarction, arrhythmias, sudden cardiac death

EENT: blurred vision

GI: nausea, vomiting, diarrhea, constipation, ulcer, anorexia

GU: urinary obstruction, lower urinary tract symptoms, breast swelling or tenderness, vaginitis, amenorrhea, infertility, decreased libido, erectile dysfunction, other sexual dysfunction, decreased testicular size, renal insufficiency

Hematologic: anemia

Musculoskeletal: increased bone pain, joint pain, decreased bone density

Metabolic: gout, hyperglycemia, hypercalcemia

Respiratory: dyspnea, chronic obstructive pulmonary disease, upper respiratory tract infection

Skin: rash, acne, diaphoresis, seborrhea

Other: hirsutism, chills, fever, hot flashes, infection, weight gain, tumor flare phenomenon, hypersensitivity, antibody formation, acute anaphylactic reactions

Interactions

Drug-diagnostic tests.Calcium, glucose, high- and low-density lipoproteins, triglycerides: increased levels

FSH, LH: initially increased, then decreased, levels

Patient monitoring

• Assess menstrual symptoms and watch for breakthrough bleeding.

Monitor neurologic status. Watch closely for signs and symptoms of cerebrovascular accident.

Closely monitor cardiovascular and respiratory status.
• Monitor blood glucose and glycosylated hemoglobin periodically.

Patient teaching

• Advise female patient to avoid pregnancy and to use a nonhormonal contraceptive method.
• Instruct patient to call prescriber if menstrual bleeding persists or breakthrough bleeding occurs.
• Inform patient that menstruation may be delayed after therapy ends.

Instruct patient to recognize and immediately report signs and symptoms of hyperglycemia, and cardiovascular or neurological adverse reactions.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the tests mentioned above.

Zoladex

(zō′lă-dĕks′)
A trademark for the drug goserelin acetate.

Zoladex®

Goserelin acetate implant, see there.

Zoladex

A brand name for GOSERELIN.
References in periodicals archive ?
His son said: "Because his medical plan was not transferred to Stansty, a result of this was he did not receive his zoladex injections.
Having considered a number of options globally, we believe it is the right choice to build the new facility in Macclesfield, which has been home to Zoladex manufacturing - and the expertise that goes along with it - for many years.
Among the cohort, Zoladex was the most extensively used LHRH agonist (72/165) and Trelstar the least prescribed (5/165), no patient was prescribed a LHRH antagonist (Table 2).
Attorney's Office in Delaware prosecuted for the government, alleging that from 1993 to 1996 the company induced doctors to bill Medicare for reimbursement for the cancer drug Zoladex, even though they actually received it for free from AstraZeneca.
patent in 2005: * Diflucan * Aredia * Engerix-B * Combivir * Lovenox * Lamisil * Lupron * Paxil * Paraplatin * Pravachol * Procrit * Prevacid * Wellbutrin SR/Zyban * Zithromax * Xenical * Zocor * Zofran * Zoladex * Zoloft Sources: NDC Health and Generic Pharmaceutical Association (Information as of January 2003)
ICI Pharmaceuticals is also one of the leading players in the Oncology segment, with products like Nolvadex, Arimidex and Zoladex.
AstraZeneca boosted sentiment after a positive update on trials for prostate cancer drug Zoladex.
Atrix says competing products Lupron and Zoladex are delivered via intra-muscular injection, whereas its Eligard is delivered just beneath the skin.
A leading maker of cardiovascular and anti-cancer treatments such as Casodex and Zoladex for prostate cancer and Nolvadex for breast cancer, the $8.
Market size and forecast for leading drugs such as Angiomax, Copaxone, Forteo, Sandostatin, Velcade, Victoza, and Zoladex has been included along with in-depth market analysis.
Scientists there developed the use of Taximofen for the treatment of breast cancer and Zoladex for prostate cancer treatment.