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Zellballen

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Zellballen
Nest-like clusters of uniform, round-to-polygonal chief cells surrounded by delicate richly vascular tissue and sustentacular cells, a pattern characteristic of paraganglioma


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The chief cells are characteristically packed in a Zellballen pattern, separated by a fibrovascular stroma and surrounded by the more basophilic sustentacular cells.
56,57) The presence of a nested zellballen growth pattern, including identification of sustentacular cells and a sinusoidal vascular pattern, are key to a correct diagnosis.
Histopathologic examination of the resected tumour revealed a paraganglioma composed of nests of mitotically quiescent polygonal cells with pink granular cytoplasm that were arranged in a characteristic Zellballen organoid growth pattern (Fig.
 
 
 
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