ZEB2


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ZEB2

A gene on chromosome 2q22.3 that encodes a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins, which localises in the nucleus and acts as a DNA-binding transcriptional repressor that interacts with activated SMADs.

Molecular pathology
ZEB2 mutations are associated with Mowat-Wilson syndrome, which is accompanied by Hirschprung disease.
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siRNA knockdown of ZEB1 and ZEB2 impaired As-transformed p53lowHBEC migration and invasion.
CONCLUSIONS: Akt activation plays a critical role in enabling As-transformed HBEC migration and invasion by promoting ZEBl and ZEB2 expression.
Moreover, we demonstrated that Akt activation drives As-transformed HBEC migration and invasion by promoting the expression of EMT-inducing transcription factors zinc-finger E-box-binding homeobox factor 1 (ZEBl)and ZEB2.
Negative control small interfering RNA (siRNA) and ON-TARGETpIus SMARTpool siRNA for ZEBl and ZEB2 were obtained from Thermo Scientific Dharmacon (Lafayette, CO, USA).
Akt activation enables As-transformed HBEC migration and invasion via promoting ZEB1 and ZEB2 expression.
To decermine the role oi ZEBl and ZEB2 in As-rransformed [p53.
By overexpressing miR-200b, applying pharmacological inhibitors to inactivate Akt or Erkl/2, and siRNA knockdown of the expression of ZEB1 and ZEB2, we established that it is the activation of Akt, and not Erkl/2, that enables As-transformed HBECs to migrate and invade.
Moreover, inactivation of Akt by treatment with a PI3K inhibitor or an Akt inhibitor similarly and significantly reduced the expression of ZEB1 and ZEB2, cell migration, and invasion.
ZEB1 and ZEB2 are EMT-inducing transcription factors (Peinado et al.
Just messing with levels of a messenger RNA from another gene known as ZEB2 throws off PTEN protein levels and can lead to melanoma in mice, Pandolfi's group reported in another paper in the Oct.
Using pregnant mice as well as human uterine tissue, the researchers have uncovered a feedback cycle involving microRNAs, proteins called ZEB1 and ZEB2, and the pregnancy-maintaining hormone progesterone, as well as genes and other factors that control contraction of the uterus.
The miR-200s block the production of two proteins called ZEB1 and ZEB2.