Downregulation of miR-429 contributes to the development of drug resistance in epithelial ovarian cancer by targeting ZEB1
EMT-associated genes (CDH2, COL1A2, COL5A2, FN1, MAP1B, MMP3, SOX10, SPP1, ZEB1
, and ZEB2), DNA repair genes (RAD51) (21) or targets relevant for cancer therapy.
,FAM122C,ZEB2,LRP1B,WIPF1,ELL2,MCFD2, RECK,SEC23A, C7orf58 miR-203 14q32.
Transcriptional regulators of EMT were upregulated in the majority of cases and included forkhead box protein C2 (FoxC2; 100%; Figure 4, A), SNAIL (89%; Figure 4, B) and ZEB1
(69%; Figure 4, C).
The ZEB-REVO builds upon features of its predecessor, the ZEB1
, with a faster scanner, simpler operation and greater versatility.
Since the loss of E-cadherin expression is considered a crucial event in EMT, EMT-TFs have been classified based on their ability to repress E-cadherin directly (SNAIL, SLUG, ZEB1
, ZEB2, etc.
05% Tween-20] at room temperature for 1 h, membranes were incubated with specific primary antibodies against CD133 (Cell Applications, San Diego, CA), aldehyde dehydrogenase 1A1 (ALDH1A1; Santa Cruz Biotechnology, Dallas, Texas), integrin/il, phosphorylated ATP-dependent tyrosine kinase (Akt; Ser 473), Akt, phosphorylated glycogen synthase kinase3[beta] (GSK3[beta]; Ser 9), GSK[beta], ZEB1
, Oct-4, Nanog, Sox2, Slug, Snail and [beta]-actin (Cell Signaling, Danvers, MA) at 4[degrees]C overnight.
For some transcription factors such as STAT1, AR, HLF, ZEB1
, TCF21, ISL1, KLF6, HOXB13, SIM2 and FOXA1, the number of interactions in the metastasis stage decreased dramatically (Table 3); the interaction numbers of other transcription factors, such as ZNF-529, FOXC1, MNX1, and JUNB, increased considerably in the metastasis stage, indicating network rewiring (Table 3).
Now marketed as the ZEB1
, and nicknamed Zebedee after the character in the French-British childrens' TV program The Magic Roundabout, the handheld instrument offers a number of benefits when it comes to surveying stockpiles or excavations, the company said.
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1
Washington, July 4 ( ANI ): Researchers have identified a transcription factor, known as ZEB1
, that is capable of converting non-aggressive basal-type cancer cells into highly malignant, tumor-forming cancer stem cells (CSCs).
Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1