HDAC2

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HDAC2

A gene on chromosome 6q21 that encodes histone deacetylase 2, which belongs to the histone deacetylase family, which form large multiprotein complexes and adeacetylate lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). HDAC2 forms transcriptional repressor complexes by associating with various proteins, including YY1—a mammalian zinc-finger transcription factor—MAD, SIN3 and N-COR; it plays a key role in transcription regulation, cell cycle progression and development.