NPY2R

(redirected from Y2 receptor)

NPY2R

A gene on chromosome 4q31 that encodes a receptor for neuropeptide Y and peptide YY. NPY receptors mediate various biological actions, including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release.
References in periodicals archive ?
11] In addition, NPY can regulate the release of neurotransmitters by acting on the Y2 receptor on the presynaptic membrane of both sympathetic and parasympathetic nerve fibers, which may play a crucial role in HR regulation.
Basic research showed that NPY could antagonize vagal bradycardia by stimulating presynaptic Y2 receptors on cardiac vagal nerve terminals and inhibit the release of the neurotransmitter acetylcholine.
Anxiolytic-like effect of the selective neuropeptide Y Y2 receptor antagonist BIIE0246 in the elevated plus-maze.
Increased stimulation of NPYergic neurons leads to the activation of presynaptic Y2 receptors and has a reciprocal effect on Y1 receptors, and thus, has overall anxiogenic and depressant effects (44,45).
Another possibility is that increased activation of NPYergic neurons to compensate for the ICV administration of CART peptide can stimulate anxiogenic presynaptic Y2 receptors.
Y2 receptor binding modulates appetite circuits in the hypothalamus and induces satiety.
Our PYY analogs, we believe, have significant potential to treat obesity because they are smaller (making them easier to be absorbed nasally), are more stable in the bloodstream and have greater specificity for the Y2 receptors than the endogenous PYY(3-36) molecule.
PYY, a high affinity Y2 receptor agonist, represents a new class of obesity drugs.
Those results suggest that Y2 receptors play an important role in the cross-talk between BDNF and NPY and are responsible, at least in part, for the control of BDNF production [56].
Plasticity of Y1 and Y2 receptors and neuropeptide Y fibers in patients with temporal lobe epilepsy.
Thus, predominance of Y1 over Y2 receptors could cause an orexigenic instead of the expected anorexigenic action of PYY (1-36).