All of the tested [Beta]-blockers demonstrated a significant reduction in heart rate with exercise compared with placebo; this included atenolol, labetalol, nadolol, celiprolol, and xamoterol.
Effects of atenolol, verapamil, and xamoterol on heart rate and exercise tolerance in digitalised patients with chronic atrial fibrillation.
Differential effects of xamoterol and verapamil on ventricular rate regulation in patients with chronic atrial fibrillation.
Placebo controlled trial of xamoterol versus digoxin in chronic atrial fibrillation.
Xamoterol improves the control of chronic atrial fibrillation in elderly patients.
Xamoterol when used alone and in combination with digoxin in patients with mild heart failure improves effort tolerance .
After baseline measurements, each patient received, in double-blind randomized order, treatment with xamoterol 200mg b.
Three patients withdrew before starting the study medication, one further patient developed diarrhoea within 1 week of starting treatment with digoxin plus xamoterol, and one patient was withdrawn because of worsening heart failure when taking xamoterol alone, having tolerated xamoterol with digoxin.
Single treatment with xamoterol caused an increase in heart rate over the whole of the 24-h period.
Table I shows that treatment with xamoterol alone produced a significantly higher heart rate during both day and night.
Digoxin Xamoterol Xanioterol Heart rate alone alone + digoxin