XIAP


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XIAP

A gene on chromosome Xq25 that belongs to the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. XIAP acts by binding to tumour necrosis-factor receptor-associated factors TRAF1 and TRAF2, inhibits apoptosis induced by menadione—a free radical inducer and IL1-beta converting enzyme—and inhibits cell-death proteases caspase-3 and caspase-7.

Molecular pathology
XIAP mutations cause X-linked lymphoproliferative syndrome.
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To calculate which protein is more likely to end up with the NO 'hot potato,' caspases or XIAP, the researchers created a new version of the Nernst equation - a 19th century mathematical equation taught in every general chemistry class.
The scientists have already developed a second generation of XIAP inhibitors that last longer in the body and have other improved biochemical properties.
Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis cell survival and proliferation.
The XIAP solution responds to market demands for an innovative insurance technology solution with increased flexibility to maintain competitive edge.
After blocking endogenous peroxidase activity and nonspecific antigen binding, the tissue sections were incubated with monoclonal antibodies against p53, AIF, XIAP, CC3 (Asp175), anti-histone H2AX, Bcl2, M30, and Ki-67 overnight in a moist chamber.
Pursuant to the agreement, Neurologix has exclusively licensed the worldwide rights, excluding China, for the use of the XIAP gene (x-linked inhibitor of apoptosis protein) for therapeutic or prophylactic purposes in the treatment of Huntington's disease.
The membranes were incubated with primary antibodies against Bax, Bad, Bc1-2, IGF1R, IGFBP3, P[beta]K, XIAP, caspases, Cyclin D (1: 2000) and GSK-3[beta], p-GSK-3[beta], IKKa, IKKI3, NFkB, p-Akt, Akt (1:1000) in Tris-buffered saline.
Immunohistochemical detection of XIAP in mesothelium and mesothelial lesions.
With AT-101, an oral, pan-Bcl-2 inhibitor compound in multiple Phase 2 clinical trials in both solid and heme tumors and a preclinical pipeline of compounds directed against MDM2 and XIAP, two key apoptosis targets, Ascenta is focused on developing a broad portfolio of apoptotic therapeutics for the treatment of cancer.