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Wolff-Chai·koff block(vulf chī'kof),
obstruction of the organic binding of iodine and its incorporation into hormone, caused by large doses of iodine; usually transient, but in large doses in susceptible people, the effect can be prolonged and cause iodine myxedema.
Synonym(s): Wolff-Chaikoff effect
[Louis Wolff; Israel Chaikoff]
the decreased formation and release of thyroid hormone in the presence of an excess of iodine.
Wolff-Chaikoff effectEndocrinology An acute adaptive response to high doses of iodine–↑ intracellular iodide blocks the organic-binding and coupling reactions in the thyroid, functionally turning off the thyroid; the WCE used to prepare the thyroid for surgery. See Hyperthyroidism.
Wolff,Louis, U.S. cardiologist, 1898-1972.
Wolff-Chaikoff block - blocking of the organic binding of iodine and its incorporation into hormone caused by large doses of iodine. Synonym(s): Wolff-Chaikoff effect
Wolff-Chaikoff effect - Synonym(s): Wolff-Chaikoff block
Wolff-Parkinson-White syndrome - an electrocardiographic pattern sometimes associated with paroxysmal tachycardia. Synonym(s): preexcitation syndrome
increased blood levels of thyroglobulin bound iodide inhibit further binding of iodide by the thyroid gland.