wobble hypothesis(redirected from Wobble base pair)
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that, in translation during protein biosynthesis, thre is a lower degree of specificity for base pairing of the 5' base of the anticodon in the RNA, allowing that RNA to make alternative hydrogen-bond interactions.See: wobble base, wobble.
wobble hypothesissee CRICK.
proposed by Francis Crick to observations that the 5′-base of the anticodon was capable of 'wobble' in its position during translation, allowing it to make alternative hydrogen bonding arrangements with several different codon bases.