About Study '0007 (NCT01412957) This Phase 3 global, multicenter, randomized, open-label study was designed to evaluate the survival benefit of Vectibix and best supportive care (BSC) compared to BSC alone in patients with chemorefractory wild-type
KRAS(exon 2) metastatic colorectal cancer (mCRC).
Following an update to the Erbitux label that was approved by the European Commission in December 2013, Erbitux is now indicated for the treatment of patients with epidermal growth factor receptor-expressing RAS wild-type
mCRC in combination with irinotecan-based chemotherapy, in firstline in combination with FOLFOX, or as a single agent in patients who have failed oxaliplatin- and irinotecan-based therapy and who are intolerant to irinotecan.
The results of the analysis of a subset of patient tumor samples from the phase 3 Cetuximab Combined With Irinotecan in First-Line Therapy for Metastatic Colorectal Cancer (CRYSTAL) trial (first-line mCRC therapy of leucovorin + 5-fluorouracil + irinotecan [FOLFIRI] with or without cetuximab; NCT00154102), (2) tested with the therascreen KRAS kit, support the application for the use of cetuximab in combination with FOLFIRI for the frontline treatment of KRAS wild-type
patients with mCRC.
Phe508del mutation, because the forward primer has a design that leads to amplification of the wild-type
coli-resistant populations were grown without further exposure to triclosan, then descendants of these bacteria may revert back to the wild-type
and regain sensitivity to triclosan.
The lack of a response to steady-state growth conditions argued strongly that branching was subject to homeostatic controls that tended to negate the effects of the growth rate differences, resulting in very consistent branching patterns in wild-type
Therefore, blocking of the EGFR by chemotherapeutic agents appears to be of potential interest only in tumours that possess wild-type
KRAS (Figure 2a and b) .
Twenty-one skulls were extracted from the carcasses of mice belonging to three genetic strains: Wild-type
C57B/6J mice (n=7), db/db mice on a C57BLKS/J background (n=7), and ob/ob mice on a C57B/6J background (n=10) (Jackson Lab, Maine, USA).
The risk could take the form of either wild-type
virus escaping from a facility or vaccine-derived polioviruses.
Through the company's research and development work, Baxter has been successful in growing wild-type
virus in its vero-cell culture, which means that the company could begin vaccine production without having to wait for high-growth or attenuated virus reassortants normally used when vaccine is produced in eggs.
The goal was for individuals to stop their antiretroviral therapies to allow drug-resistant HIV to revert back to wild-type
virus and then start a megaHAART regimen.
virus is usually found in an HIV+ person who is not taking meds.