Wernicke-Korsakoff syndrome


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Related to Wernicke-Korsakoff syndrome: Wernicke's encephalopathy, thiamine, pellagra, beriberi

Wernicke-Korsakoff syndrome

 [ver´nĭ-kĕ kor´sah-kof€]
a disorder of the central nervous system, usually associated with chronic alcoholism and nutritional deficiency such as severe thiamine depletion. It is characterized by a combination of motor and sensory disturbances (wernicke's encephalopathy) and disordered memory function (korsakoff's syndrome). It typically has an abrupt onset, manifested by ocular motility, ataxia, diplopia, and horizontal nystagmus. Many patients are unaware of their unsteady gait, decreased mental acuity, and other signs of cognitive dysfunction.



There usually is an immediate improvement in ocular disturbances once therapy with thiamine is begun. The ataxia and diminished perceptual function and concept formation show a much slower rate of improvement. Only about 20 per cent of those with Korsakoff's syndrome fully recover. The mortality rate for the syndrome may be as high as 17 per cent during the acute phase. (See also alcoholism.)

Wer·nic·ke-Kor·sa·koff syn·drome

(vern'ik-ĕ kōr'să-kof), [MIM*277730]
the coexistence of Wernicke and Korsakoff syndromes, with characteristic lesions in the mammilary bodies and medial dorsal thalamic nucleus.

Wer·nic·ke-Kor·sa·koff syn·drome

(vern'ik-ĕ kōr'să-kof), [MIM*277730]
the coexistence of Wernicke and Korsakoff syndromes, with characteristic lesions in the mammilary bodies and medial dorsal thalamic nucleus.

Wernicke-Korsakoff syndrome

(vĕr′nĭ-kē-kôr′sə-kôf′, -kŏf′, -nĭ-kə-)
n.
A neurological disorder usually associated with severe alcoholism and subsequent thiamine deficiency, marked by the signs of Wernicke's encephalopathy in the acute phase followed by the chronic memory loss and disorientation of Korsakoff syndrome.

Wernicke-Korsakoff syndrome

the coexistence of Wernicke's encephalopathy and Korsakoff's syndrome.

Wernicke-Korsakoff syndrome

Alcoholic encephalopathy, Korsakoff psychosis, Wernicke's disease Neurology Organic mental disease linked to chronic alcohol abuse, usually accompanied by thiamin deficiency Clinical Memory loss, confabulation

Wer·nic·ke-Kor·sa·koff syn·drome

(ver'ni-kĕ-kōr'sĕ-kof sin'drōm)
The coexistence of Wernicke and Korsakoff syndromes.

Wernicke-Korsakoff syndrome

A late form of brain damage occurring in long-term alcoholics who rely mainly on alcohol for nutrition and who are severely deficient in the B vitamin thiamine. One form, Wernicke's encephalopathy, starts suddenly with incoordination, staggering, paralysis of eye movements and mental confusion progressing to stupor and death. Patients can be saved by a timely injection of a large dose of thiamine. The other form, Korsakoff's psychosis, features severe memory loss with inability to store new data and a process of confabulation, in which the affected person makes up stories to fill in the gaps in the memory. Korsakoff's psychosis is usually irreversible and proceeds to profound DEMENTIA. (Karl Wernicke, 1848–1904, German neurologist; and Sergei Sergeivitch Korsakov, 1853–1900, Russian psychiatrist and neurologist).

Wernicke-Korsakoff syndrome

A combination of symptoms, including eye-movement problems, tremors, and confusion, that is caused by a lack of the B vitamin thiamine and may be seen in alcoholics.

Korsakoff,

(Korsakov), Sergei S., Russian neurologist and psychiatrist, 1853-1900.
Korsakoff psychosis - Synonym(s): Korsakoff syndrome
Korsakoff syndrome - an alcohol amnestic syndrome. Synonym(s): amnestic psychosis; amnestic syndrome; dysmnesic psychosis; Korsakoff psychosis; polyneuritic psychosis
Wernicke-Korsakoff encephalopathy
Wernicke-Korsakoff syndrome - see under Wernicke

Wernicke,

Karl, German neurologist, 1848-1905.
Gayet-Wernicke syndrome - Synonym(s): Wernicke syndrome
Wernicke aphasia - impairment in the comprehension of spoken and written words. Synonym(s): Bastian aphasia; sensory aphasia
Wernicke area - Synonym(s): Wernicke center
Wernicke center - the region of the cerebral cortex thought to be essential for understanding and formulating coherent, propositional speech. Synonym(s): sensory speech center; Wernicke area; Wernicke field; Wernicke region; Wernicke zone
Wernicke cramp - psychogenic muscle cramp. Synonym(s): cramp neurosis
Wernicke disease - Synonym(s): Wernicke syndrome
Wernicke encephalopathy - Synonym(s): Wernicke syndrome
Wernicke field - Synonym(s): Wernicke center
Wernicke radiation - the massive, fanlike fiber system passing from the lateral geniculate body of the thalamus to the visual cortex. Synonym(s): optic radiation
Wernicke reaction - in hemianopia, a reaction due to damage of the optic tract, consisting in loss of pupillary constriction when the light is directed to the blind side of the retina. Synonym(s): Wernicke sign
Wernicke region - Synonym(s): Wernicke center
Wernicke sign - Synonym(s): Wernicke reaction
Wernicke syndrome - a condition encountered in chronic alcoholics, characterized by disturbances in ocular motility, pupillary alterations, nystagmus, and ataxia with tremors. Synonym(s): Gayet disease; Gayet-Wernicke syndrome; superior hemorrhagic polioencephalitis; Wernicke disease; Wernicke encephalopathy
Wernicke zone - Synonym(s): Wernicke center
Wernicke-Korsakoff encephalopathy
Wernicke-Korsakoff syndrome - the coexistence of Wernicke and Korsakoff syndromes.
Wernicke-Mann hemiplegia - extremity hemiplegia that is partial. Synonym(s): Wernicke-Mann paralysis
Wernicke-Mann paralysis - Synonym(s): Wernicke-Mann hemiplegia

Wer·nic·ke-Kor·sa·koff syn·drome

(ver'ni-kĕ-kōr'sĕ-kof sin'drōm) [MIM*277730]
The coexistence of Wernicke and Korsakoff syndromes.

Wernicke-Korsakoff syndrome

an inflammatory hemorrhagic encephalopathy in humans due to thiamin deficiency. Called also Wernicke's encephalopathy (disease, syndrome).
References in periodicals archive ?
The Wernicke-Korsakoff Syndrome and Related Neurologic Disorders Due to Alcoholism and Malnutrition.
Erythrocyte transketolase activity in the Wernicke-Korsakoff syndrome.
It would help prevent the brain disease Wernicke-Korsakoff syndrome, which affects the heaviest drinkers.
This is referred to as Wernicke-Korsakoff syndrome, or Korsakoff's psychosis, and includes significant anterograde and retrograde memory loss, often with confabulation.
Abnormality of a thiamine enzyme in-patients with Wernicke-Korsakoff syndrome.
McEntee has more than 19 years of research experience in CNS areas including Alzheimer's, Panic Disorders, Age-Associated Cognitive Disorders, Depression, Headache and Wernicke-Korsakoff Syndrome.