Werner syndrome


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Related to Werner syndrome: progeria, ataxia telangiectasia

Wer·ner syn·drome

(wĕr'nĕr), [MIM*277700]
a premature aging disorder presenting sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p.

Wer·ner syn·drome

(wĕr'nĕr), [MIM*277700]
a premature aging disorder presenting sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p.

Werner syndrome

(vĕr′nər) or

Werner's syndrome

(-nərz)
n.
An autosomal recessive disorder characterized by short stature and the appearance of premature aging after puberty, with early development of conditions such as cataracts, cardiovascular disease, osteoporosis, and malignancies.

Werner syndrome

A rare autosomal recessive progeroid syndrome (OMIM:277700) characterised by premature onset of multiple age-related disorders, including atherosclerosis, cancer, type-2 diabetes, ocular cataracts, osteoporosis, and death by age 47, often due to myocardial infarction.

Molecular pathology
Defects of WRN, which encodes a DNA helicase responsible for maintaining genomic integrity, cause Werner syndrome.

Wer·ner syn·drome

(ver'ner sin'drōm)
A premature aging disorder consisting of sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p.

Werner,

Otto, German physician, 1879-1936.
Werner disease - hereditary disorder characterized by premature aging. Synonym(s): progeria adultorum; Werner syndrome
Werner syndrome - Synonym(s): Werner disease
References in periodicals archive ?
To do this, they created a cellular model of Werner syndrome by using a cutting-edge gene-editing technology to delete WRN gene in human stem cells.
Our study connects the dots between Werner syndrome and heterochromatin disorganization, outlining a molecular mechanism by which a genetic mutation leads to a general disruption of cellular processes by disrupting epigenetic regulation," says Izpisua Belmonte.
A case of a delusional psychotic syndrome in the setting of Werner syndrome.
A case of myocardial infarction in a patient with Werner syndrome.
Calcaneal osteosarcoma associated with Werner syndrome.
Microwave-assisted synthesis of a pyrazolyl ketone library for evaluation as p38 MAPK inhibitors in Werner syndrome cells
Research on the effects of telomerase on Werner syndrome cells was conducted by scientists at Geron and published in the April issue of the FASEB Journal in a paper entitled "Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains.
Martin and a Japanese research group headed by Toshio Ogihara of the Osaka University Medical School have recently started to study two known normal versions of the Werner syndrome gene.
People born with Werner syndrome start the decline to old age in their twenties.
Schellenberg of the University of Washington in Seattle and his colleagues located the Werner syndrome gene on chromosome 8.