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Because the criteria for ascertaining anti-SARS-CoV activity in this screen were set at 100% inhibition of CPE, and as high doses of interferons may result in severe clinical side effects, we chose to conduct further evaluations only in the interferons that showed complete inhibition from initial screen, namely, Wellferon, Multileron, Betaleron, and Alferon.
Betaferon, Alferon, Multiferon, Wellferon, and ribavirin inhibited CPE in SARS-CoV-infected Vero E6 cells, in decreasing order of potency.
100]) at different virus titers Virus load Ribavirin Wellferon Retaferon Alferon (PFU/well) ([micro]g/mL) (IU/mL) (IU/mL) (IU/mL) 10,000 10,000 500,000 10,000 10,000 1,000 10,000 5,000 1,0o0 1,000 100 1,000 500 10 100
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