bupropion

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bupropion

[bu-pro´pe-on]

a compound structurally similar to amphetamine, used in the form of the hydrochloride salt as an antidepressant and as an aid in smoking cessation to reduce the symptoms of nicotine withdrawal; administered orally.

bupropion

/bu·pro·pi·on/ (bu-pro´pe-on) a monocyclic compound structurally similar to amphetamine, used as the hydrochloride salt as an antidepressant and as an aid in smoking cessation.

bupropion

(byo͞o-prō′pē-ŏn′)

A drug, C₁₃H₁₈ClNO, used in its hydrochloride form for the treatment of depression and as an aid in smoking cessation. It is a weak inhibitor of norepinephrine and dopamine reuptake in the central nervous system.

buPROPion

[boo͡prō′pē·on]

a heterocyclic mood-elevating drug used to treat some types of depression (trademark: Wellbutrin) and also to promote smoking cessation (trademark: Zyban).

bupropion

Zyban^® Psychiatry An antidepressant Side effects Dry mouth, insomnia Contraindications Seizures, bulimia

bupropion

A drug used in the treatment of tobacco, drug and alcohol dependency. Bupropion reacts adversely with a wide range of other drugs and may induce seizures in sensitive persons. When used, a strict regime is necessary. A brand name is Zyban.

Bupropion

An antidepressant medication given to smokers for nicotine withdrawal symptoms. It is sold under the trade name Zyban.

Mentioned in: Smoking-Cessation Drugs

bupropion (byōō´prō´pēon),

n brand names: Wellbutrin, Zyban;
drug class: antidepressant;
action: weak uptake inhibitor of dopamine, serotonin, norepinephrine; mechanism unknown;
uses: treatment of depression and anxiety disorders; tobacco cessation.

References in periodicals archive ?

The chart below (21) shows the results of bioequivalence tests of the two drugs by measuring concentration of medicine over time for the 150 mg doses of Budeprion and Wellbutrin XL.

Generics substitution, bioequivalence standards and oversight of international pharmaceutical producers: Complex issues facing the FDA

Previously, the company has submitted to the FDA a sANDA with the requested study, demonstrating bioequivalence of its Bupropion HCl ER Tablets USP (XL), 300 mg, to WELLBUTRIN XL Tablets, 300 mg.

Mylan Inc wins FDA approval of sANDA for Bupropion Hydrochloride Extended-Release Tablets USP (XL) 300 mg

The planned withdrawal of Budeprion XL 300 mg is the result of studies conducted by the company and FDA aimed at addressing reports of reduced efficacy from patients who were switched to generic forms of Wellbutrin XL 300 mg made more than 5 years ago.

Bupropion genetic yanked over bioequivalence

The bioequivalence problem was confirmed in an FDA-sponsored study conducted in 2010, comparing the bioequivalence of the Impax/Teva product to Wellbutrin XL 300 mg in 24 healthy adults, which determined that the generic tablets "fail to release bupropion into the blood at the same rate and to the same extent as Wellbutrin XL 300 mg," according to the statement.

Bioequivalence problem results of generic Drug

Wellbutrin XL helps patients to comply with therapy by a once daily dose.

Wellbutrin XL

The main focus on Thursday will be on the management's guidance for this year, as there are likely to be several generic challenges to core products, including Zofran - used to prevent nausea and vomiting associated with chemotherapy - and Wellbutrin XL, which treats depression.

BP's big profits are the first step to restoring reputation

However, pharmaceuticals firm GlaxoSmithKline found itself going in the other direction following a US court ruling which could open the door to a generic version of its antidepressant pill Wellbutrin XL.

THE WEEK'S REVIEW

However, pharmaceuticals firm GlaxoSmlthKline found itself going in the other direction following a US court ruling which could open the door to a generic version of its antidepressant pill Wellbutrin XL.

LONDON MARKET

Extended-release bupropion is marketed as Wellbutrin XL by GlaxoSmithKline.

SAD indication approved for antidepressant

Wellbutrin XL, a newer formulation, can be taken once daily.

Antidepressants

CPI-300 represents a new, high-strength formulation of Bupropion hydrochloride (HCl), the active ingredient in Wellbutrin XL.

FDA gives approval to IntelGenx CPI-300 anti-depressant

Wellbutrin XL was originally developed by Biovail and has been distributed by Glaxo in the United States since 2003.