Our previous pharmacokinetic studies revealed the considerably low oral bioavailability (2%, 50 mg/kg, Table S1) of WEL in rats, which resulted from the extensive first-pass metabolism of WEL in the gastrointestinal tract.
The objectives of the present study included (1) to identify through ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) and high-performance liquid chromatography-solid-phase extraction-nuclear magnetic resonance spectroscopy (HPLC-SPE-NMR) the WEL metabolites formed in rats following an oral administration of 50 mg/kg WEL; (2) to determine the uridine diphosphate-glucuronosyltransferases (UGTs) responsible for WEL glucuronidation using human liver microsomes (HLMs), human intestine microsomes (HIMs), human kidney microsomes (HKMs), and recombinant human UGT enzymes; and (3) to explore the possible mechanisms of WEL regioselective glucuronidation.
Networks is an electricity distribution company that owns, develops and maintains the electricity network of lines, cables, substations and associated infrastructure.
is a not-for-profit organization whose primary purpose is to increase the number of women serving on corporate boards by recognizing and connecting accomplished women and further expanding their influence within their respective business communities.
is not party to any swap obligations.
To test their catchability as well as growth, British researchers examined recaptures of tagged wels
in a small catch-and-release lake in England *.
Digital communication technology provider DRI Corporation (DRI) (Nasdaq:TBUS) announced on Wednesday that it has appointed Oliver Wels
as president of DRI Corporation, effective 25 March 2010.
DALLAS -- DRI Corporation (DRI) (NASDAQ: TBUS), a digital communications technology leader in the global surface transportation and transit security markets, announced today that Oliver Wels
was appointed President of DRI Corporation, effective March 25, 2010.
Contact point(s): Holding Wels
Immobilien GmbH & Co.
Founded in 1990, WELS is an affiliate of London-based International House, one of the largest English language and teacher training networks in the world.
Major organization : HOLDING WELS IMMOBILIEN GMBH & CO.
Implementing agency : Klinikum Wels