Warburg effect


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Warburg effect

The observation—first made by Otto Heinrich Warburg—that most malignant cells get their energy from anaerobic metabolism, at rates of glycolysis of up to 200-fold greater than oxidative metabolism of pyruvate in mitochondria. This effect led Warburg to assume that the fundamental change in cancer was metabolic rather than genetic. Some practitioners of alternative forms of healthcare continue to believe the Warburg effect can be exploited by reducing the energy available to malignant cells using hydrazine sulphate and other agents.

Warburg effect

The reliance of most cancer cells on glycolysis rather than oxidation to meet their metabolic needs.
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He observed that a characteristic of malignant cells is their continued reliance on glycolysis even when the oxygen supply is restored to the cell, a condition now known as the Warburg effect.
Noteworthy, cancerous cells under normal conditions (in the presence of abundant oxygen) still convert pyruvate to lactate, in parallel to pyruvate oxidation; that is, the Warburg effect is observed (Figures 1(a) and 1(b)).
This shift in metabolism is known as the Warburg Effect.
This edition has been revised and updated to include recent advances and information on the tumor microenvironment, metastatic dissemination, tumor immunology, cancer stem cells, the epithelial-mesenchymal transition, multi-step tumorigenesis, invasion and metastasis, mutation of cancer cell genomes, epigenetic contributions, microRNA involvement, and the Warburg effect, with more on traditional therapy and a new list of key techniques.
The observation, called the Warburg effect, demonstrated that the normal energy producing processes in the cell are disrupted in cancer cells, preventing them from using metabolic pathways in the cell's mitochondria (often called the cell's "power plants").
The Warburg effect sets in motion the biochemical activities that provide the fuel and materials required for rapid tumor cell growth and division.
This result is consistent with protein breakdown and utilization as well as the Warburg effect in kidney cancer tumors.
in aerobic conditions most cancer cells display a high rate of glycolysis with lactate production in the cytosol, known as the Warburg effect.
Max is associated with MYC, a gene that drives tumor growth and the Warburg Effect in cancer.
1970: Pedersen and his group discovered that cancers exhibiting the Warburg effect have a reduced respiration rate relative to their tissue of origin.
Cantley discovered pyruvate kinase M2 (PKM2) as a "hub" to integrate growth factor signaling and aerobic glycolysis, a new evolution in the understanding of the Warburg effect.