He observed that a characteristic of malignant cells is their continued reliance on glycolysis even when the oxygen supply is restored to the cell, a condition now known as the Warburg effect
Noteworthy, cancerous cells under normal conditions (in the presence of abundant oxygen) still convert pyruvate to lactate, in parallel to pyruvate oxidation; that is, the Warburg effect
is observed (Figures 1(a) and 1(b)).
This phenotype became known as the Warburg Effect
This shift in metabolism is known as the Warburg Effect
This edition has been revised and updated to include recent advances and information on the tumor microenvironment, metastatic dissemination, tumor immunology, cancer stem cells, the epithelial-mesenchymal transition, multi-step tumorigenesis, invasion and metastasis, mutation of cancer cell genomes, epigenetic contributions, microRNA involvement, and the Warburg effect
, with more on traditional therapy and a new list of key techniques.
The observation, called the Warburg effect
, demonstrated that the normal energy producing processes in the cell are disrupted in cancer cells, preventing them from using metabolic pathways in the cell's mitochondria (often called the cell's "power plants").
The Warburg effect
sets in motion the biochemical activities that provide the fuel and materials required for rapid tumor cell growth and division.
This result is consistent with protein breakdown and utilization as well as the Warburg effect
in kidney cancer tumors.
in aerobic conditions most cancer cells display a high rate of glycolysis with lactate production in the cytosol, known as the Warburg effect
Max is associated with MYC, a gene that drives tumor growth and the Warburg Effect
1970: Pedersen and his group discovered that cancers exhibiting the Warburg effect
have a reduced respiration rate relative to their tissue of origin.
Cantley discovered pyruvate kinase M2 (PKM2) as a "hub" to integrate growth factor signaling and aerobic glycolysis, a new evolution in the understanding of the Warburg effect