WWOX

WWOX

A gene on chromosome 16q23.3-q24.1 that encodes a putative oxidoreductase, which acts as a tumour suppressor and plays a role in apoptosis, as well as in TGFB1 signalling and TGFB1-mediated cell death. WWOX may act synergistically with p53/TP53 to control genotoxic stress-induced cell death, and may play a role in tumour necrosis factor (TNF)-mediated cell death. It inhibits Wnt signalling, and is required for normal bone development.
References in periodicals archive ?
Comparative genomic hybridization studies have identified deletions of the fragile site tumor suppressors WWOX and FHIT.
Chang has been devoted to the discovery and development of the tumor suppressor WW domain-containing oxidoreductase (designated WWOX, FOR or WOX1).
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.
44) Several genes important in the pathogenesis of pancreatic cancer such as APC, (45) TSLC/IGSF4, (46) SOCS-1, (47) cyclin D2, (48) RASSF1A, (49) WWOX, (50) RUNX3, (51) CDH13, (52) DUSP6, (53) HHIP, (54) and SLC5A8 (55) undergo aberrant methylation, leading to reduced expression or loss of expression.
The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.
The WWOX gene plays a crucial role in controlling cancer progression.
The publication focuses on the most recent progress in understanding the function of WWOX as a tumor suppressor.
Because WWOX contains two WW domains, it was an ideal protein to analyze with ProChart, Cytogen's proprietary, comprehensive, experimentally validated database of protein-protein signaling interactions.