WWOX

WWOX

A gene on chromosome 16q23.3-q24.1 that encodes a putative oxidoreductase, which acts as a tumour suppressor and plays a role in apoptosis, as well as in TGFB1 signalling and TGFB1-mediated cell death. WWOX may act synergistically with p53/TP53 to control genotoxic stress-induced cell death, and may play a role in tumour necrosis factor (TNF)-mediated cell death. It inhibits Wnt signalling, and is required for normal bone development.
References in periodicals archive ?
Objective: To detect the expression of CD133, E-cadherin and WWOX in colorectal cancer, analyze the correlations and pathological significance of the biomarkers.
Pathologic specimens were retrieved for immunohistochemical examination of the expressions of CD133, WWOX and E-cadherin.
One school of thought suggested that genomic instability during cancer progression causes collateral damage to genes residing within CFSs, such as WWOX and FHIT.
miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene.
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.
Comparative genomic hybridization studies have identified deletions of the fragile site tumor suppressors WWOX and FHIT.
44) Several genes important in the pathogenesis of pancreatic cancer such as APC, (45) TSLC/IGSF4, (46) SOCS-1, (47) cyclin D2, (48) RASSF1A, (49) WWOX, (50) RUNX3, (51) CDH13, (52) DUSP6, (53) HHIP, (54) and SLC5A8 (55) undergo aberrant methylation, leading to reduced expression or loss of expression.
The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.