WT1


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WT1

A gene on chromosome 11p13 that encodes a transcription factor with a central role in urogenital development. WT1 displays complex tissue-specific and polymorphic imprinting pattern, with biallelic and monoallelic expression from the maternal and paternal alleles in different tissues. WT1 mRNA undergoes RNA editing, a tissue-restricted and developmentally regulated process.

Molecular pathology
WT1 is mutated in a small subset of patients with Wilm's tumours.
References in periodicals archive ?
The A allele causes the loss of affinity sites for WT1, AP-2 a, having exclusive affinity with C/EBP alpha, a transcription factor that serves as a co-activator, binding to the promoter regions of several lipid metabolism genes, including SCD, and is associated with lipid deposition in the adipocyte proliferation and growth processes (Reardon el al.
Gene name Gene description MAP3K7 Mitogen-activated protein kinase kinase kinase 7 HDAC9 Histone deacetylase 9 CFTR Cystic fibrosis transmembrane conductance regulator ETHE1 Ethylmalonic encephalopathy 1 MCM3AP Minichromosome maintenance deficient 3 associated protein SPIB Spi-B transcription factor WT1 Wilms' tumor 1 BID BH3 interacting domain death agonist C1QTNF3 Clq and tumor necrosis factor related protein 3 S0D2 Superoxide dismutase 2 SFRS1 Splicing factor, arginine/serine-rich 1 UBE2N Ubiquitin-conjugating enzyme E2N Gene name Glycyrrhizin Silymarin Change (folds) FDR Change (folds) FDR MAP3K7 -5.
2010) Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.
NPHS2 (encoding podocin), WT1 (exons 8 and 9) and LAMB2 (encoding laminin-[beta]2) are causes of two thirds of cases of nephrotic syndrome with onset in the first year of life.
The researchers could then differentiate them further into cells expressing SIX2, SALL1, and WT1, important markers of the metanephric cap mesenchyme, a critical stage of kidney differentiation.
Almost 1/3 of sporadic aniridia cases have PAX6 deletion and deletion of another contiguous gene, the WT1 gene (these two are separated from each other by 700 kb in 11p13).
6) Resistance of all basement wall from surface to surface WT1 Window Type 1 Type of window for 1 South-most window(s) WT2 Window Type 2 Type of window for 1 East-most window(s) WT3 Window Type 3 Type of window for 1 North-most window(s) WT4 Window Type 4 Type of window for 1 West-most window(s) FT Frame Type Frame type for all 1 windows on house WWR1 Window-to-Wall Window-to-wall ratio 0.
The WT1 protein is overexpressed in leukemias and is in part responsible for why the cells have become leukemic.
Dichos conjuntos son la escala de tonos enteros, en su version WT1, un conjunto que resulta como la combinacion de HEX con WT1, y el conjunto 8-24.
The antibodies used were CK7, CK20, CKAE1/AE3, EMA , CEA , WT1, Inhibin, vimentin, calretinin, CD117, CD99, PLAP, CD30, OCT4, AFP, KI67, CD20, CD79a, CD3, CD5, LCA, CKHMW, CKLMW, Desmin, Synaptophysin and chromogranin, from (DAKO, Denmark).
PAX6 geninin 11p13 bolgesinde yer alan bir tumor baskilayici gen olan WT1 geninin komsulugunda bulunmasi nedeniyle, bu bolgenin mikrodelesyonlari siklikla PAX6 ve WT1 genlerini birlikte etkiler.
6,4,14 On immunohistochemistry (IHC), MA's are focally positive for CK7 and strongly and diffusely positive with antibodies to WT1 and CD57 as are maturing Wilms tumours and nephrogenic rests.