At that point, WOSCOPS leaders advised study participants' primary care physicians to seriously consider putting their patients on long-term statin therapy.
For WOSCOPS participants who got a 20% drop in LDL during 5 years of pravastatin from a baseline of 190 mg/dL, as was typical, the number of patients who needed to be treated (NNT) for 5 years to prevent one cardiovascular hospital admission over a 20-year period was six.
White said, but the key to why the legacy effect was seen in WOSCOPS despite the use of pravastatin--a less-potent statin--but not to date in other statin trials may lie in the fact that WOSCOPS was a primary prevention study and its participants had the youngest mean age of all the major statin trials.
12 AFCAPS/TexCAPS, Air Force/Texas Coronary Atherosclerosis Prevention Study; ALLHAT-LLT, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart AttackTrial; ASCOT-LLA, Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm; CHD, coronary heart disease; hsCRP, high-sensitivity C-reactive protein; JUPITER, Justification for me Use of Statins in Prevention: an Intervention Trial Evaluating HosuvasTatin; LDL-C, low-density lipoprotein cholesterol; MEGA, Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese; MI, myocardial infarction; WOSCOPS
, West of Scotland Coronary Prevention Study.