Vulnerable Plaque

(redirected from Vulnerable plaques)
An atheromatous plaque in an arterial wall, which has abundant macrophages, gobs of lipids and cholesterol, and is usually covered by a thin fibrous cap which may rupture. The repeated cycle of rupture and healing is regarded as the major mechanism of arterial stenosis in atherosclerotic heart disease, myocardial infarction and strokes
References in periodicals archive ?
Vulnerable plaques are defined as plaques which are highly prone to rupture with rapid progression and eventually lead to clinical events, especially the subtle cognition impairment.
Together with our current results, P4H[alpha]1 overexpression appeared a potential therapeutic target to stabilize vulnerable plaques.
When risk appears to be high, imaging tests may be ordered to look for vulnerable plaques in the arteries.
NanoHybrids is developing a contrast agent for intravascular imaging for IVUS/IVPA (Intravascular Ultrasound/Intravascular Photoacoustic) systems to target macrophages in vulnerable plaques, thus facilitating better and more cost-effective clinical decision making in the treatment of atherosclerosis.
The pathological mechanisms leading from stable lesions to the formation of vulnerable plaques remain in doubt, and the associated clinical events are unpredictable.
The research was based on a previous long-term study, which demonstrated there are many molecular pathways contributing to the development of vulnerable plaques and subsequent heart attacks.
When arteries become inflamed, the vulnerable plaques also produce an enzyme known as lipoprotein-associated phospholipase A2 (Lp-PLA2).
Biomechanical parameters play a major role in the generation and rupture of vulnerable plaques.
The ability to assess vulnerable plaques nondestructively with near-histologic resolution during in vivo, intracoronary imaging may significantly enhance the evaluation and management of patients with coronary artery disease.
Statins are also highly effective at preventing a first heart attack, likely by stabilizing the core of soft, vulnerable plaques and making them less likely to rupture.
The rationale for the search of biomarkers of vulnerable plaques seems sound.