ADAMTSbd13

(redirected from Von Willebrand factor-cleaving protease)

ADAMTSbd13

An ADAMTSs family enzyme encoded by ADAMTS13 on chromosome 9q34, which is identical to vWFCP (von Willebrand factor-cleaving protease, the name by which it is more commonly known in haematology). ADAMTS13/vWFCP degrades large vWF multimers by cleaving monomeric subunits, the absence of which (due to mutations) causes thrombotic thrombocytopenic purpura.
ADAMTS13 mRNA is expressed in liver, placenta, ovary, various other tissues, and in platelets.
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References in periodicals archive ?
Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family.
Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.
5) The disease is the result of a circulating inhibitor against the von Willebrand factor-cleaving protease, ADAMTS13.
Deficient activity of von Willebrand factor-cleaving protease in chronic relapsing thrombotic thrombocytopenic purpura.
Activity levels of the von Willebrand factor-cleaving protease (ADAMTS13), which is involved in blood clotting, were available for eight of the 15 patients.
Symptom Nausea 5 71 Abdominal pain 6 86 Fever 5 71 Fatigue 5 71 Treatment Plasmapheresis 6 86 Dialysis 0 0 Other illness Hepatitis C 7 100 Sepsis 7 100 Endocarditis 3 43 Renal failure 7 100 Abbreviations: BUN = blood urea nitrogen; LDH = lactate dehydrogenase; ADAMTS13 = the von Willebrand factor-cleaving protease.
Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13).
von Willebrand factor-cleaving protease (ADAMTS-13) activity determination in the diagnosis of thrombotic microangiopathies: the Swiss experience.
Severe deficiency of the specific von Willebrand factor-cleaving protease (ADAMTS 13) activity in a subgroup of children with atypical hemolytic uremic syndrome.
The von Willebrand factor-cleaving protease (ADAMTS-13) and the diagnosis of thrombotic thrombocytopenic purpura (TTP).
CE test on von WILLEBRAND FACTOR-CLEAVING PROTEASE IN THROMBOTIC THROMBOCYTOPENIC PURPURA
MLO and Northern Illinois University (NIU), DeKalb, IL, are co-sponsors in offering continuing education units (CEUs) for this issue's article on von WILLEBRAND FACTOR-CLEAVING PROTEASE IN THROMBOTIC THROMBOCYTOPENIC PURPURA.