von Willebrand factor


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fac·tor VIII

in the clotting of blood, also known as: antihemophilic factor A (Brinkhous), antihemophilic globulin (1) (Patek and Taylor), antihemophilic globulin A (Cramer), plasma thromboplastin factor (Ratnoff), plasma thromboplastin factor A (Aggeler), thromboplastic plasma component (Shinowara), thromboplastinogen (Quick), prothrombokinase (Feissly), platelet cofactor (Johnson), plasmokinin (Laki), thrombokatilysin (Leggenhager), and proserum prothrombin conversion accelerator. Factor VIII participates in the clotting of the blood by forming a complex with factor IXa, platelets, and calcium and by enzymatically catalyzing the activation of factor X. Deficiency of factor VIII is associated with classic hemophilia A. Factor VIIIC is the coagulant component of factor VIII which, in normal people, circulates in the plasma complexed with Factor VIIIR (von Willebrand factor), the plasma factor VIII-related protein, a large glycoprotein component that is synthesized by endothelial cells and megakaryocytes, and circulates in the plasma where it binds to arteries that have lost their endothelial cell linings, creating a surface to which platelets adhere. Disorders involving factor VIIIR comprise a heterogenous group of abnormalities called von Willebrand disease. A deficiency of factor VIII can lead to impaired blood coagulation.

von Willebrand factor

Hematology A large–> 20,000 kD multimeric molecule composed of ± 200 kD monomers, synthesized by vascular endothelium, megakaryocytes and platelets; vWF's hemostatic efficiency is related to multimer size. See Rocket electrophoresis.

von Willebrand factor

A plasma protein secreted by endothelial cells that helps platelets to adhere to the damaged lining of blood vessels.

von Willebrand factor (vWF)

A protein found in the blood that is involved in the process of blood clotting.

von Willebrand factor

the property of factor VIII necessary for normal platelet function; abbreviated VWF. Called also factor VIIIvwf.
References in periodicals archive ?
Type 2M von Willebrand disease variant characterized by abnormal von Willebrand factor multimerization.
After researchers adjusted for potential confounding risk factors, those women in the top quartile for von Willebrand factor levels were at fivefold greater risk of having atrial fibrillation than were those women in the lowest quartile.
9 People with von Willebrand disease have a deficiency in or impairment of a protein called von Willebrand factor, an important component in the blood clotting process.
About von Willebrand disease Von Willebrand disease (VWD) is the most common hereditary bleeding disorder in the United States, and is caused by a deficiency or abnormality of von Willebrand factor, a protein in the blood that is necessary for normal blood clotting.
Lot 10 - Coagulation Factor VIII von Willebrand factor plasma + 1000 IU / fl.
3 von Willebrand Factor 450 IU / 500 IU vial 100,200
Thrombotic thrombocytopenic purpura, or TTP, is a rare blood disorder that arises from uncontrolled activation of von Willebrand Factor (vWF), a protein which under normal conditions plays a key role in maintaining the normal balance between bleeding and clotting.
The concentrate of human coagulation factor VIII, von Willebrand factor comprising the treatment of von Willebrand~s disease the number 7 000 000 IU von Willebrand FactorCoagulation factor must be supplied with the kit allowing his administration.
Dci - Factor Ix Clottinglot 7 - + Plasma Coagulation Factor Viii Von Willebrand Factor 500 Iu Fl.
VWD is caused when von Willebrand factor, a protein in the blood that is necessary for clotting, is either missing or not working properly.
Bio/Data then created a von Willebrand Factor Assay (also known as Ristocetin Cofactor Assay) kit, and it has grown in usage and popularity.
Contract awarded for Von willebrand factor antigen, reagent for the determination