virus-associated he·mo·phag·o·cyt·ic syndrome (h  m -f g -s t k)n. A syndrome that resembles malignant histiocytosis and follows infection with a herpes virus, such as Epstein-Barr virus. |
virus-associated hemophagocytic syndrome
A hemophagocytotic condition seen in immunocompromised–♂:♀ ratio, 1:1 and in non-immunocompromised–♂:♀ ratio, 4:1 subjects, often in a background of DNA
virus–eg, CMV, EBV, herpesviruses, and adenovirus and rubella infections; VAHS may accompany brucellosis, candidiasis, leishmaniasis, TB, salmonellosis, GVHD, hemolytic anemia Clinical Hepatosplenomegaly, lymphadenopathy, pulmonary
infiltrates, pancytopenia–with a depleted BM, skin rash DiffDx Lymphoma, malignant histiocytosis, sinus histiocytosis with massive lymphadenopathy, lymphomatoid granulomatosis
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