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Vidaza |
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Vidaza, a trademark for azacitidine. azacitidine Warning - Hazardous drug! Vidaza Pharmacologic class: Pyrimidine antimetabolite Therapeutic class: Antineoplastic Pregnancy risk category D ActionUnclear. Thought to exert antineoplastic effect by causing DNA hypomethylation and direct cytotoxicity on abnormal hematopoietic bone marrow cells. Cytotoxicity causes death of rapidly growing cells, including cancer cells no longer responsive to normal growth control mechanisms. AvailabilityPowder for injection (lyophilized): 100-mg single-use vials ⊘Indications and dosages ➣ Treatment of the following myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusion), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia Adults: For first treatment cycle: 75 mg/m2 subcutaneously daily for 7 days; for subsequent treatment cycles, repeat cycle every 4 weeks. Dosage may be increased to 100 mg/m2 if beneficial effect doesn't occur after two cycles and no toxicity (other than nausea and vomiting) develops. Patient should be treated for at least four cycles. Continue therapy as long as patient benefits from it. Dosage adjustment• Based on hematologic response (after administration of recommended dosage for first cycle) Off-label uses• Acute myeloid leukemia Contraindications• Hypersensitivity to drug or mannitol PrecautionsUse cautiously in: Administration• Obtain CBC, liver function tests, and serum creatinine level before starting drug.
Adverse reactionsCNS: fatigue, headache, confusion, dizziness, anxiety, aggravated fatigue, depression, insomnia, lethargy, weakness, rigors, malaise, hypoesthesia CV: chest pain, cardiac murmur, tachycardia, hypotension, peripheral edema, syncope EENT: rhinorrhea, epistaxis, sinusitis, nasopharyngitis, pharyngitis, postnasal drip GI: nausea, vomiting, diarrhea, constipation, anorexia, abdominal pain or tenderness, abdominal distention, dyspepsia, hemorrhoids, dysphagia, gingival bleeding, oral mucosal petechiae, stomatitis, tongue ulcers, mouth hemorrhage GU: dysuria, urinary tract infection Hematologic: anemia, thrombocytopenia, leukopenia, neutropenia, febrile neutropenia, lymphadenopathy, aggravated anemia, postprocedural hemorrhage Musculoskeletal: myalgia, muscle cramps, arthralgia, limb pain, back pain Respiratory: cough (possibly productive), dyspnea, exertional or exacerbated dyspnea, upper respiratory tract infection, pneumonia, crackles, wheezing, decreased breath sounds, pleural effusion, rhonchi, atelectasis Skin: lesion, rash, pruritus, herpes simplex, increased sweating, urticaria, dry skin, skin nodule, erythema, pallor, cellulitis Other: decreased appetite, weight loss, fever, pitting edema, hematoma, night sweats, peripheral swelling, infection site reaction, transfusion reaction, chest-wall pain, postprocedural or other pain InteractionsDrug-diagnostic tests. Potassium: decreased Patient monitoring• Monitor CBC during therapy. Patient teaching☞ Instruct patient to call prescriber immediately if rash, easy bruising or bleeding, or respiratory symptoms develop. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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