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vidarabine |
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vidarabine /vi·dar·a·bine/ (vi-dar´ah-bēn) adenine arabinoside (ara-A), a purine analogue that preferentially inhibits viral DNA synthesis; used as an antiviral agent to treat herpes simplex keratitis or keratoconjunctivitis.
vidarabine [vider′əbēn] an antiviral agent. Also called adenine arabinoside. indications This drug is an ophthalmic ointment prescribed to treat keratoconjunctivitis and nearby epithelial or superficial keratitis caused by herpes simplex virus type 1 or type 2. contraindications Known hypersensitivity to this drug prohibits its use, and it should not be used for ophthalmic ulcers that are sterile. adverse effects Local irritation, photophobia, and corneal edema may occur in topical ophthalmic applications. vidarabine [vi-dar´ah-bēn] adenine arabinoside (ara-A), a purine analogue that inhibits DNA synthesis; used as an antiviral agent to treat herpes simplex keratitis and keratoconjunctivitis.
vidarabine (vidar´ n (ophthalmic),
brand name: Vira-A Ophthalmic; class: antiviral; action: inhibits DNA synthesis by blocking DNA polymerase; use: keratoconjunctivitis due to herpes simplex virus. vidarabine a purine analog, adenine arabinoside (ara-A), that inhibits DNA synthesis; used as an antiviral agent to treat herpesvirus infection.
antiviral agents Substances which inhibit the growth of a virus (e.g. herpes) by inhibiting DNA or RNA synthesis. Common agents include aciclovir (acyclovir), idoxuridine, ganciclovir, trifluoridine (trifluorothymidine) and vidarabine. See herpetic keratitis; virus.
vidarabine Ara-A Virology An IV or topical antiviral active against DNA viruses; it is a competitive inhibitor of DNA-dependent DNA polymerase, and ↓ mortality of neonatal HSV, HSV encephalitis Toxicity Thrombocytopenia, leukopenia,
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