vidarabine /vi·dar·a·bine/ (vi-dar´ah-bēn) adenine arabinoside (ara-A), a purine analogue that preferentially inhibits viral DNA synthesis; used as an antiviral agent to treat herpes simplex keratitis or keratoconjunctivitis.
vidarabine
vidarabine [vi-dar´ah-bēn]
vidarabine (vidar´
bēn´),
vidarabine
vi·dar·a·bine (v -d r  -b n )n. A purine nucleoside obtained from a species of Streptomyces and used in the treatment of herpes simplex infections. |
vidarabine
[vider′əbēn]
an antiviral agent. Also called adenine arabinoside.
indications This drug is an ophthalmic ointment prescribed to treat keratoconjunctivitis and nearby epithelial or superficial keratitis caused by herpes simplex virus type 1 or type 2.
contraindications Known hypersensitivity to this drug prohibits its use, and it should not be used for ophthalmic ulcers that are sterile.
adverse effects Local irritation, photophobia, and corneal edema may occur in topical ophthalmic applications.
vidarabine [vi-dar´ah-bēn]
adenine arabinoside (ara-A), a purine analogue that inhibits DNA synthesis; used as an antiviral agent to treat herpes simplex keratitis and keratoconjunctivitis.
vidarabine (vidar´
bēn´),n (ophthalmic),
brand name: Vira-A Ophthalmic;
class: antiviral;
action: inhibits DNA synthesis by blocking DNA polymerase;
use: keratoconjunctivitis due to herpes simplex virus.
brand name: Vira-A Ophthalmic;
class: antiviral;
action: inhibits DNA synthesis by blocking DNA polymerase;
use: keratoconjunctivitis due to herpes simplex virus.
vidarabine
a purine analog, adenine arabinoside (ara-A), that inhibits DNA synthesis; used as an antiviral agent to treat herpesvirus infection.
antiviral agents
Substances which inhibit the growth of a virus (e.g. herpes) by inhibiting DNA or RNA synthesis. Common agents include aciclovir (acyclovir), idoxuridine, ganciclovir, trifluoridine (trifluorothymidine) and vidarabine. See herpetic keratitis; virus.
vidarabine
Ara-A Virology An IV or topical antiviral active against DNA viruses; it is a competitive inhibitor of DNA-dependent DNA polymerase, and ↓ mortality of neonatal HSV, HSV encephalitis Toxicity Thrombocytopenia, leukopenia,
N&V, diarrhea, irritability, tremors, ataxia, paresthesias, hallucinations, ↓ renal, liver function
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