In models of ischemic stroke and peripheral vascular disease, treatment with either the Company's natural peptide, TXA127, or its cyclic analog, PanCyte, resulted in increased blood flow and histologic evidence of vasculogenesis
(new blood vessel formation).
This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis
and endothelial cell growth, promoting cell migration, and inhibiting apoptosis.
Vascular endothelial growth factor has been mapped to 6pter-p21 and is a multifunctional cytokine involved with angiogenesis, vasculogenesis
, and cell survival.
Judah Folkman, who pioneered the fields of angiogenesis and vasculogenesis
and shed light on the link between blood supply and neoplastic disease, the newly released special double issue (Volume 6, Number 3-4) of Lymphatic Research and Biology includes a series of papers that reflect the research impact of one of the pre-eminent physician-scientists of his generation.
Interferon-alpha promotes abnormal vasculogenesis
in lupus: a potential pathway for premature atherosclerosis.
VEGF is a highly specific mitogen for endothelial cells, inducing angiogenesis as well as the permeabilization of blood vessels and playing a central role in the regulation of vasculogenesis
Transforming growth factor-[beta]: Vasculogenesis
, angiogenesis, and vessel wall integrity.
The abstract of the paper, "Transmyocardial Revascularization Enhances Myocardial Vasculogenesis
and Hemodynamic Function" is available on the AATS website (http://www.
Chronic inflammation and vasculogenesis
is present to some extent in the natural course of OA.
It induces vasculogenesis
from preendothelial cells and angiogenesis from preexisting capillaries (Carmeliet 2000; Ferrara 1999).
The SDF-1 / CXCR4 / CXCR7 axis has been shown to play a role in stem cell as well as leukemic cell mobilization and homing, vasculogenesis
, tumor growth, transendothelial migration, invasion and metastasis.
Regulation of vasculogenesis
and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells.