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von Willebrand factor
(redirected from VWF antigen)

   Also found in: Wikipedia 0.01 sec.
von Willebrand factor (vWF)
A protein found in the blood that is involved in the process of blood clotting.

von Willebrand factor
the property of factor VIII necessary for normal platelet function; abbreviated VWF. Called also factor VIIIvwf.

von Willebrand factor
Hematology A large–> 20,000 kD multimeric molecule composed of ± 200 kD monomers, synthesized by vascular endothelium, megakaryocytes and platelets; vWF's hemostatic efficiency is related to multimer size. See Rocket electrophoresis.


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12) Circulating plasma vWF antigen is a marker of generalized endothelial dysfunction and atherothrombosis.
As microalbuminuria increases in diabetic nephropathy, vWF antigen level also increases.
In addition, this deficiency may account for the variability between patients with similar levels of VWF antigen, but strikingly different bleeding histories.
 
 
 
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