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Willebrand disease

, von Willebrand disease (vil′ĕ-brant″)
[Erik Adolph von Willebrand, Finnish physician, 1870–1949]


A congenital autosomal dominant bleeding disorder caused by a deficiency of von Willebrand factor (a protein that helps platelets stick to injured blood vessels during the formation of blood clots. Inadequate amounts of the protein result in easy bruising or bleeding. Common symptoms of the disorder are frequent bleeding from the gums after brushing the teeth, frequent or prolonged nosebleeds, heavy menstrual periods, or heavy bleeding after childbirth or surgery.

The disease is the most common inherited bleeding disorder. Unlike hemophilia A and B, which are X-linked, it affects both genders. Despite its high prevalence in the population (about 3% of Americans are affected), vWD is often undiagnosed because many affected people have only mild episodes of bleeding. vWD can be diagnosed by the demonstration of low levels of von Willebrand factor in the blood; by a prolonged bleeding time; or by factor VIII deficiency (one function of von Willebrand factor is to carry clotting factor VIII in plasma). Treatments for heavy bleeding episodes (or for necessary surgeries) may include the administration of clotting factors containing von Willebrand factor or factor VIII or synthetic vasopressin.


von Willebrand's disease.
References in periodicals archive ?
Type 1 VWD represents partial quantitative deficiency in VWF that results in decreased normally functioning VWF (12), which is able to mediate platelet adhesion and binds to collagen and factor VIII under normal physiological conditions.
Case Age Dx Epistaxis Easy Bleeding Surgery/bleeding bruising gums 1 17 GT rare yes yes no/no 2 15 GT no yes yes no/no 3 15 BSS yes yes no tooth ex-traction/ yes 4 15 BSS yes yes yes tooth ex-traction/ yes 5 15 BSS yes yes yes no/no 6 14 Low VWF yes yes no no/no 7 25 VWD yes yes yes tooth type ex-traction/ 3 yes 8 34 VWD?
epistaxis particularly lasting for more than 30 min, causing anaemia or hospital admission seen in platelet disorders, VWD (Grade C, level IV).
Interestingly, a possible mild type 1 VWD plus mild platelet dysfunction was identified by testing on this repeat (but medication free) occasion.
In addition, Pensaert (3) described nonsuppurative encephalomyelitis in 70%-100% of animals showing neurologic signs and in 20%-60% of animals with VWD syndrome.
This system will provide almost all the energy needs for VWD during the day and send back power to the utility grid which the utility can supply to other consumers, especially at peak times.
5 to 10 mL/min Detection VWD UV/VIS Fluid Delivery Module C02: 0.
The three men left the scene in the direction of Coventry Road in a red Rover Sterling car, registration K225 VWD.
The company, known as VWD, has more than 80,000 subscribers to its newswires and newsletters, in addition to a market-data terminal business.
This lack of awareness may contribute to the low rate of diagnosis (It is estimated that over 99% of those with VWD have not been diagnosed.
2] alleles in symptomatic patients with 5 types of VWD and found that the frequency of allele 2 among patients with type I VWD (0.
German news agency VWD reported Monday that the G-7 meeting will be held in Italy instead of Washington as initially scheduled due to the terrorist attacks in the United States.