VIPoma


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VIPoma

 
an endocrine tumor, usually a type of islet cell tumor, that produces excessive amounts of vasoactive intestinal polypeptide, producing severe diarrhea, hypokalemia, and hypochlorhydria, leading to renal failure that can be fatal.

VI·Po·ma

(vi-pō'mă),
An endocrine tumor, usually originating in the pancreas, which produces a vasoactive intestinal polypeptide believed to cause profound cardiovascular and electrolyte changes with vasodilatory hypotension, watery diarrhea, hypokalemia, and dehydration.
[vasoactive intestinal polypeptide + G. -ōma, tumor]

VIPoma

/VIP·oma/ (vĭ-po´mah) an endocrine tumor, usually an islet cell tumor, that produces vasoactive intestinal polypeptide, causing a syndrome of watery diarrhea, hypokalemia, and hypochlorhydria, leading to potentially fatal renal failure. Alternatively, vipoma.

vipoma

/vip·oma/ (vĭ-po´mah) VIPoma.

VIPoma

[vipō′mə]
a type of pancreatic tumor that causes changes in secretion of vasoactive intestinal polypeptide (VIP). VIP causes dilation of blood vessels throughout the body and secretion of fluid and salt in the intestinal tract, resulting in diarrhea. The VIP effects mimic the symptoms of cholera (severe diarrhea, hypokalemia, and hypochlorhydria) and can result in death from dehydration and subsequent kidney failure if treatment is not begun early. See also vasoactive intestinal polypeptide.
A vasoactive intestinal peptide-producing tumour of the pancreas associated with a cholera-like syndrome in absence of gastric hypersecretion

VIPoma

Oncology A VIP–vasoactive intestinal peptide-producing tumor of the pancreas, which is associated with a cholera-like syndrome in absence of gastric hypersecretion. See VIPoma syndrome.

VIP·o·ma

(vi-pō'mă)
An endocrine tumor, usually originating in the pancreas, which produces a vasoactive intestinal polypeptide believed to cause profound cardiovascular and electrolyte changes with vasodilatory hypotension, watery diarrhea, hypokalemia, and dehydration.
[vasoactive intestinal polypeptide + G. -ōma, tumor]

VIPoma

A neuroendocrine tumour of tissue that stains for chromogranin A and is rich in vasoactive intestinal peptide, hence the name. The condition features persistent large-volume watery diarrhoea.

VIP·o·ma

(vi-pō'mă)
Endocrine tumor, usually originating in pancreas, which produces a vasoactive intestinal polypeptide believed to cause profound cardiovascular and electrolyte changes with vasodilatory hypotension, watery diarrhea, hypokalemia, and dehydration.
[vasoactive intestinal polypeptide + G. -ōma, tumor]
References in periodicals archive ?
2 Differential diagnosis of IBS includes SIBO, carbohydrate/fructose malabsorption, lactose intolerance, yeast overgrowth or hypersensitivity, parasitic infection, large intestine bacterial overgrowth or infection, abdominophrenic dyssynergia, celiac disease, IBD: Crohn's/ulcerative colitis, VIPoma, Zollinger-Ellison syndrome, cancer (pancreatic, stomach, small intestine), H.
Pancreatic neuroendocrine tumors Tumor Prevalence Malignancy Rate amongst PETs Insulinoma 40% 10% Gastrinoma 20% 60% Non-Functioning 35% 85% Glucagonoma Rare 80% VIPoma Rare 70% Somatistatinoma Rare 70% Tumor Clinical Symptoms, Features Insulinoma Hypoglycemia, elevated serum C-peptide Gastrinoma Gastric hypersecretion leading to post/bulbar ulcers and diarrhea.
4]) Senna Magnesium citrate Bisacodyl Milk of Magnesia Phenolphthalein Polyethylene glycol solution Chronic alcohol ingestion Magnesium-containing antacids Bacterial infections Carbohydrate malabsorption Bile acid malabsorption Lactase deficiency Neoplasm Lactulose Gastrinoma Sorbitol VIPoma Villous adenoma of rectum Inflammatory Bowel Disease Celiac disease Hyperthyroidism
The clinical picture has been referred to as VIPoma syndrome; Verner-Morrison syndrome; and watery diarrhea, hypokalemia, and achlorhydria (WDHA) syndrome.
51,52) They can be categorized into hyperfunctioning (insulinoma, gastrinoma, glucagonoma, vipoma, and somatostatinoma) and nonhyperfunctioning tumors that can be located in the pancreas or peripancreatic tissue.
The more uncommon but generally larger hyperfunctioning (eg, glucagonoma, vipoma, somatostatinoma) and nonhyperfunctioning tumors present with a slightly lower signal intensity on T1WI and a moderate signal intensity on T2WI.
Dynamic gadolinium-enhanced MR imaging of pancreatic VIPoma in a Patient with Verner-Morrison syndrome.
Pancreatic tumors classification * Primary tumors Exocrine Ductal adenocarcinoma Serous cystic tumor Mucinous cystic tumor Solid-pseudopapillarymucinous tumor Acinar cell carcinoma Anaplastic carcinoma Pancreatoblastoma Endocrine Insulinoma Gastrinoma Glucagonoma Vipoma Somatostatinoma Nonhyperfunctiong tumor Nonepithelial tumor Lymphoma Teratoma Lymphangioma Lipoma Neural tumors Secondary tumors * Table data adapted from Solcia E, Capella C, Kloppel G.
102,129,130) Indeed, mutations are detected in about 30% of NF-PENs, whereas insulinomas, gastrinomas, glucagonomas, and VIPomas show a mutation rate of 7%, 36%, 67%, and 44%, respectively.
Similarly, VIPomas, somatostatinomas, and GRFomas may also arise outside of the pancreas.