CAV1

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CAV1

A gene on chromosome 7q31.1 that encodes caveolin 1, the main scaffolding protein of caveolae plasma membranes in most cells. Caveloin 1 links integrin subunits to the tyrosine kinase FYN, an early step in coupling integrins to the Ras-ERK pathway which drives cell cycle progression; CAV1 is a tumour suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and form a stable hetero-oligomeric complex with other colocalising proteins.

Molecular pathology
CAV1 mutations are linked to congenital generalised lipodystrphy (Berardinelli-Seip syndrome) type 3.
References in periodicals archive ?
Integration of Dejima Direct(TM) with VIP21 Offers Advanced Search
VIP21+ will provide Veritext clients with an advanced method of accessing, leveraging, and searching the deposition transcripts stored on Veritext's VIP21 service over various modalities.
com), a leading provider of application interface technology for enterprise and mobile applications, VIP21 customers can now search the service with natural language queries over the Web, email, and wireless devices, such as BlackBerry(R) Wireless Handhelds(TM) from Research In Motion (RIM) (Nasdaq:RIMM).
The addition of Dejima Direct to VIP21 empowers our clients with anytime, anywhere access to transcripts in the most intuitive way -- via their own words and in as little as one step.
In addition to current tools that allow users to search VIP21 through various criteria available on drop-down lists, Veritext has now enabled the service to accept natural language queries such as "transcripts with the word Penicillin" or "transcripts with defendant Smith.
Natural language searches of transcripts stored on VIP21 can be conducted using criteria including case name, plaintiff name, defendant name, scheduling attorney, deposing attorney, witness name, field of expertise, city, state and date range.
Our attorneys and paralegals are very excited about the enhanced search capabilities and improved access to VIP21," said Manny Pokotilow, Managing Partner of Philadelphia-based Caesar Rivise, a Veritext VIP21 client.
of Pepper Hamilton LLC in Philadelphia, also a VIP21 client, echoed Pokotilow 's sentiments, and said the ability to search the Veritext VIP21 transcript database via the BlackBerry would yield multiple benefits for his firm.