up-regulation

up-regulation

 [up reg-u-la´shun]
increase in expression of a gene; in the narrowest sense, that in which transcription of a specific mRNA is increased, but also used more broadly to refer to increase in mRNA levels for a particular gene from any cause, such as increased stability of the specific mRNA.

up-regulation

/up-reg·u·la·tion/ (up reg-u-la´shun) increase in expression of a gene; most narrowly, that due to increased transcription of a specific mRNA, but also used more broadly for increase in mRNA levels for the gene by any means.

up-regulation

[up reg-u-la′shun]
increase in expression of a gene; in the narrowest sense, that in which transcription of a specific mRNA is increased, but also used more broadly to refer to an increase in mRNA levels for a particular gene from any cause, such as increased stability of the specific mRNA. See also down-regulation.
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References in periodicals archive ?
This may suggest an up-regulation of the metabolic pathway for morphine.
The research team's previous data demonstrated that TB4 treatment induces myelin basic protein synthesis and oligodendrogenesis by up-regulation of p38 MAPK.
The combination of surface topographies is designed to create an optimal host-bone response and actively participate in the fusion process by promoting the up-regulation of osteogenic and angiogenic factors necessary for bone growth, encouraging natural production of bone morphogenetic proteins, and "creating the potential for a faster and more robust fusion," the company claims.
Choroidal neovascularisation (CNV) develops in response to the up-regulation of multiple pro-angiogenic cytokines, including vascular endothelial growth factor (VEGF), in the context of an abnormal extracellular matrix.
When compared with SW620 cells, the up-regulation of activated caspase-3 and cleaved PARP was much less in SW620 Ad300 cells.
The allowed claims cover use of PV-10 in combination with systemic inhibitors of immune system down-regulation, such as anti-CTLA-4, PD-1 and PD-L1 antibodies, along with enhancers of immune system up-regulation, such as IL-2 and interferon-gamma.
These results were only partially confirmed by the results of the protein plasmas levels which found very significant up-regulation of IL-2 and down regulation of IL-6, borderline p-values for IL-8 and non-significant results for TNF-[alpha].
The scientists report that when these cells were exposed to a well-known molecular activator of EoE - an immune hormone called Interleukin 13 (IL-13) - it caused dramatic up-regulation of CAPN14.
To determine if functions identified in Arabidopsis are conserved across other taxa cytokinin-induction and oxidative-stress tests will be performed and up-regulation of Clade III CRFs will be confirmed via qRT-PCR.
Taken together, our data suggest that the antiproliferative effect of NAC is partially mediated by intracellular ROS production, the inhibition of NF-kB activity, and the activation of PI3K- and/or MEK/Erk-related intracellular signaling pathways, which lead to up-regulation of Cyr61 expression.
loss of miR-99a/100 leading to up-regulation of FGFR3 before its mutation).
Microarray studies revealed that several of the E2 analogs cause a dramatic up-regulation of genes in signaling pathways related to OPC differentiation and myelin sheath production.