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A protein that mediates the transport of one molecule or ion through a membrane without known coupling to the transport of any other molecule or ion.
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They are also an important Ca2+ buffer, sequestering the ion through a uniporter that creates an electrochemical potential to pull the ion into the cell.
Using an "integrative genomics" strategy that included RNAi technology, the study identified for the first time the mitochondrial calcium uniporter (MCU), which regulates calcium transport into mitochondria.
Our approach combined genomics, physiology, biochemistry, and pharmacology to firmly establish MCU as the essential protein component of the mitochondrial calcium uniporter.