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Umbrella Cell

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Umbrella Cell
A term for a multinucleated superficial cell of the bladder’s transitional epithelium, which has vacuolated cytoplasm. Umbrella cells are thin but cover multiple underlying transitional cells in a parasol-like fashion. They can be identified immunohistochemically by the presence of uroplakins—Ia, Ib, II, and III


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Umbrella cells are usually used to fill the opening between other coverage cells.
Although outside the scope of the present study, findings with the rabbit primary culture system (29) suggest that further manipulation of the cell culture technique could modify the level of differentiation of the UROtsa cell cultures toward either the highly differentiated umbrella cell or the undifferentiated basal cell.
 
 
 
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