USP8


Also found in: Acronyms.

USP8

A gene on chromosome 15q21.2 that encodes an enzyme which deubiquitinates target proteins (e.g., BIRC6, KIF23, STAM2, RASGRF1, ESCRT-0, EGFR, EPS15,  RASGRF1, RNF41, YWHAE, YWHAG and YWHAZ), preventing their degradation and thus playing an important regulatory role in protein turnover.
Mentioned in ?
References in periodicals archive ?
USP8 was originally identified to enhance cell growth as its expression increases upon serum stimulation in cancer cells.
Two recent studies demonstrated that the USP8 gene is frequently mutated in corticotroph adenomas.
Recently, it was also demonstrated that USP8 inhibitor impairs the growth of gefitinib-resistant and -sensitive nonsmall cell lung cancer cells by decreasing receptor tyrosine kinase (RTK) expression.
Moreover, we observed that the inhibitory effects of USP8 inhibitor on mouse ACTH-secreting pituitary adenoma cell viability are, at least in part, due to apoptosis induction, accompanied by increased cleaved caspase 3 and Bax and decreased Bcl-2 as previously reported in other experimental models.
We finally investigated whether USP8 inhibitor had any effect on ACTH secretion in AtT20 cells.
In conclusion, USP8 inhibitor could inhibit proliferation, abolishes clonogenic ability, and induces apoptosis in pituitary corticotroph tumor cell-AtT20 cells.