USP28

USP28

A gene on chromosome 11q23 that encodes a deubiquitinase involved in DNA damage response, which interacts with isoform 1 of FBXW7; following DNA damage, it and dissociates from FBXW7 leading to degradation of MYC. USP28 is involved in DNA damage-induced apoptosis by deubiquitinating certain proteins of the DNA  damage pathway (e.g., CLSPN). It is also acts at the G2 DNA damage checkpoint by deubiquitinating CLSPN and preventing its degradation by the anaphase-promoting complex/cyclosome (APC/C). It is downregulated by hypoxia.
References in periodicals archive ?
For example, KIF1C (kinesin family member 1C) and USP28 (ubiquitin specific peptidase 28) mutations, which are clonally expanded in metastasis, preexist at levels of [less than or equal to] 1% in primary breast tumors (8), and clinical resistance-causing KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (gastrointestinal stromal tumor) and EGFR (lung adenocarcinoma) mutations can be present in tumors at levels <<1% (36, 37).
soluble; EGFR, epidermal growth factor receptor; KIF1C, kinesin family member 1C; USP28, ubiquitin specific peptidase 28; KIT, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.