UCP2


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UCP2

A gene on chromosome 11q13 that encodes one of the mitochondrial uncoupling proteins (UCP), which belong to the family of mitochondrial anion carrier proteins (MACPs). UCPs separate oxidative phosphorylation from ATP synthesis (the so-called mitochondrial proton leak); facilitate the transfer of anions from the inner to the outer mitochondrial membrane, and protons from the outer to the inner mitochondrial membrane; and reduce the mitochondrial membrane potential in mammalian cells. UCPs contain the 3 homologous protein domains of MACPs; UCP2 is expressed in many tissues, especially in skeletal muscle, and thought to play a role in thermogenesis, obesity and diabetes.
References in periodicals archive ?
Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion.
Identification of UCP2 mapping nearby the load score peak of STR1 revealed unexpected interesting implications for the renal injury phenotype of SHRSP.
The researchers found that natural birth triggered UCP2 expression in the neurons located in the hippocampal region of the brain.
These findings suggest that inhibiting UCP2 might alleviate type 2 diabetes, says Lowell.
10:15 The Effect of Fatty Acid Synthase Inhibitor on PPAR-[gamma] and UCP2 Expression During Steatotic Liver Ischemia Reperfusion.
Craig Warden will look for the effects of fructose on the activity of two genes, UCP2 and UCP3.
In contrast, newfound gene UCP2 is at work in every human tissue Warden has checked, especially ordinary white fat and muscle, he said.
74] showed that genipin or UCP2 inhibition triggers ROS-dependent nuclear translocation of the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and formation of autophagosomes.
In addition to brain development, UCP2 plays a role in breaking down fat - which suggests UCP2 might get kickstarted by natural birth as a way for a baby animal to transition to breast feeding.
Cannabis treatment in the obese group resulted in up-regulation of CB1, GLUT2, UCP2 and PKB, relative to the obese control group, while c-MYC levels were down-regulated, relative to the lean control group.